MENDEL AND THE GENE IDEA

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MENDEL AND THE GENE IDEA CHAPTER 14

WHAT YOU NEED TO KNOW: Terms associated with genetics problems: P, F1, F2, dominant, recessive, homozygous, heterozygous, phenotype, genotype. How to derive the proper gametes when working a genetics problem. The difference between an allele and a gene. How to read a pedigree.

Gregor Mendel Austrian monk Brought experimental and quantitative approach to genetics Bred pea plants to study inhertance Why peas? Control _____________ (self- vs. cross-pollination) Many varieties available Short generation time

P (parental) generation = true breeding plants F1 (first filial) generation = offspring F2 (second filial) generation = F1 offspring

Alleles: alternate versions of a gene

7 characters in pea plants Dominant vs. Recessive (expressed) or (hidden)

MENDEL’S PRINCIPLES Alternate version of genes (____________) cause variations in inherited characteristics among offspring. For each character, every organism inherits _____ allele from ________ parent. If 2 alleles are different, the ________________ allele will be fully expressed; the _____________ allele will have no noticeable effect on offspring’s appearance. Law of Segregation: the 2 alleles for each character ________________ during __________ formation.

Law of Segregation

dominant (P), recessive (p) homozygous = 2 same alleles (PP or pp) heterozygous = 2 different alleles (Pp)

Phenotype: expressed physical traits Genotype: genetic make-up

Punnett Square Device for predicting offspring from a cross Example: Pp x Pp (P=purple, p=white) Genotypic Ratio: Phenotypic Ratio:

Testcross: determine if dominant trait is homozygous or heterozygous by crossing with _____________ (pp)

Law of Independent Assortment: Each pair of alleles segregates (separates) independently during gamete formation Eg. color is separate from shape

Monohybrid cross: study ___ character eg. flower color Dihybrid cross: study ___ characters eg. flower color & seed shape

Dihybrid Cross Example: AaBb x AaBb

The laws of probability govern Mendelian inheritance Rule of Multiplication: probability that 2+ independent events will occur together in a specific combination  _____________ probabilities of each event P(A) x P (B) Ex. 1: probability of throwing 2 sixes on a pair of dice 1/6 x 1/6 = 1/36 Ex. 2: probability of having 5 boys in a row ½ x ½ x ½ x ½ x ½ = 1/32 Ex. 3: If cross AABbCc x AaBbCc, probability of offspring with AaBbcc is: Answer: ½ x ½ x ¼ = 1/16

The laws of probability govern Mendelian inheritance Rule of Addition: Probability that 2+ mutually exclusive events will occur  add together individual probabilities Ex. 1: chances of throwing a die that will land on 4 or 5? 1/6 + 1/6 = 1/3

Segregation of alleles and fertilization as chance events

Extending Mendelian Genetics The relationship between genotype and phenotype is rarely simple Complete Dominance: heterozygote and homozygote for dominant allele are indistinguishable Eg. YY or Yy = yellow seed Incomplete Dominance: F1 hybrids have appearance that is between that of 2 parents Eg. red x white = pink flowers

Codominance: phenotype of ___________________ is expressed Eg. red hair x white hairs = roan horses Multiple Alleles: gene has _____ alleles Eg. human ABO blood groups Alleles = _______ IA,IB = __________

Blood Typing Phenotype (Blood Group) Genotype(s) Type A IAIA or IAi IBIB or IBi Type AB IAIB Type O ii

Blood Transfusions Blood transfusions must match blood type Mixing of foreign blood  clumping  death Rh factor: protein found on RBC’s (Rh+ = has protein, Rh- = no protein)

Blood Typing Problem: A man who is heterozygous with type A blood marries a woman who is homozygous with type B blood. What possible blood types might their children have?

Polygenic Inheritance: the effect of 2 or more __________ acting upon a single phenotypic character (eg. _____ color, ___________)

Nature and Nurture: both ___________ and ________________ factors influence phenotype Hydrangea flowers vary in shade and intensity of color depending on acidity and aluminum content of the soil.

Mendelian Inheritance in Humans Pedigree: diagram that shows the relationship between parents/offspring across 2+ generations Woman = Man = Trait expressed:

Pedigree Analysis

Genetic Disorders Autosomal Recessive Autosomal Dominant Cystic fibrosis (CF) Tay-Sachs disease _____________ disease Phenylketonuria (PKU) Huntington’s disease (HD) Lethal dominant allele