Beyond Statin Therapy

Program Goals

Overview of Dyslipidemia Management

Patient Case 1

Challenges of Using Clinical Trial Data to Assess Statin Intolerance

PCSK9 Inhibitors in Statin Intolerance ODYSSEY Alternative

Safety of Alirocumab Skeletal Muscle AEs

Incidence of Muscle AEs With Statins PRIMO Study

GAUSS Evolocumab in Statin Intolerance

GAUSS-2

GAUSS-3 Study Design 2 Double-Blind Phases

GAUSS-3 Phase A Study Drug Discontinuation Events

GAUSS-3 Efficacy and Safety for Evolocumab

Patient Case 2

2016 ACC Expert Consensus Role of Nonstatin Therapies in LDL-C Lowering

2017 AACE Guidelines for the Management of Dyslipidemia

PCSK9 Inhibitor CV Outcomes Trials

FOURIER Trial Design

FOURIER LDL-C Reduction

FOURIER CV Outcomes

Improving Access to PCSK9 Inhibitors

Abbreviations

Abbreviations (cont)