PPARα: Savior or savage? Jochen G. Schneider, Clay F. Semenkovich  Cell Metabolism  Volume 2, Issue 6, Pages 341-342 (December 2005) DOI: 10.1016/j.cmet.2005.11.006 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 An unexpected process mediated by PPARα Activation of the nuclear receptor PPARα by fibrate drugs is known to improve systemic lipid metabolism through events occurring predominantly in the liver. Activation of hepatic PPARα can also cause peroxisomal proliferation, liver dysfunction, and tumors (especially in rodents). Recent findings by Gizard and colleagues show that activation of PPARα in vascular smooth muscle cells surprisingly induces the tumor suppressor p16 and decreases smooth muscle proliferation, suggesting a potentially novel strategy for treating restenosis and atherosclerosis. Cell Metabolism 2005 2, 341-342DOI: (10.1016/j.cmet.2005.11.006) Copyright © 2005 Elsevier Inc. Terms and Conditions