“Prohibitin”g CRAF/MAPK Activation with Rocaglamides

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“Prohibitin”g CRAF/MAPK Activation with Rocaglamides Krishnaraj Rajalingam, Thomas Rudel Chemistry & Biology Volume 19, Issue 9, Pages 1077-1078 (September 2012) DOI: 10.1016/j.chembiol.2012.09.004 Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 Rocaglamides Disrupt PHB-CRAF Interaction Leading to Inactivation of CRAF Kinase Activation of RAS recruits CRAF to the plasma membrane where prohibitin is required for the displacement of 14-3-3 from Ser259 to facilitate CRAF activation. PP2A dephosphorylates Ser259, leading to phosphorylation at Ser 338, and dephosphorylates Tyr341, by activating kinases, leading to full activation of CRAF kinase. Rocaglamides directly disrupt PHB1-CRAF interaction, thus, rendering CRAF kinase inactive. Chemistry & Biology 2012 19, 1077-1078DOI: (10.1016/j.chembiol.2012.09.004) Copyright © 2012 Elsevier Ltd Terms and Conditions