Volume 27, Issue 1, Pages (January 2011)

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Volume 27, Issue 1, Pages 19-34 (January 2011) Antimicrobial Pharmacokinetic and Pharmacodynamic Issues in the Critically Ill with Severe Sepsis and Septic Shock Julie M. Varghese, BPharm (Hons), Jason A. Roberts, PhD, BPharm (Hons), FSHP, Jeffrey Lipman, MBBCh, FCICM, MD Critical Care Clinics Volume 27, Issue 1, Pages 19-34 (January 2011) DOI: 10.1016/j.ccc.2010.09.006 Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 1 The relationship between pharmacokinetics (PK) and pharmacodynamics (PD). Critical Care Clinics 2011 27, 19-34DOI: (10.1016/j.ccc.2010.09.006) Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 2 Flow diagram summarizing the effects of pathophysiologic changes on PK/PD parameters of hydrophilic antibiotics. AUC, area under the curve; Cmax, maximum drug concentration; Cmin, minimum drug concentration; CL, clearance; CO, cardiac output; MIC, minimum inhibitory concentration; PK/PD, pharmacokinetic/pharmacodynamic; Vd, volume of distribution. Critical Care Clinics 2011 27, 19-34DOI: (10.1016/j.ccc.2010.09.006) Copyright © 2011 Elsevier Inc. Terms and Conditions

Fig. 3 Flow diagram summarizing the effects of pathophysiologic changes on PK/PD parameters of lipophilic antibiotics. AUC, area under the curve; Cmax, maximum drug concentration; Cmin, minimum drug concentration; CL, clearance; CO, cardiac output; MIC, minimum inhibitory concentration; PK/PD, pharmacokinetic/pharmacodynamic; Vd, volume of distribution. Critical Care Clinics 2011 27, 19-34DOI: (10.1016/j.ccc.2010.09.006) Copyright © 2011 Elsevier Inc. Terms and Conditions