J. Gonçalves-Pereira, A. Martins, P. Póvoa

Slides:

Advertisements

Similar presentations

Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages

Advertisements

Laboratory diagnosis and biosafety issues of biological warfare agents

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

L. Boyanova Clinical Microbiology and Infection

Gut bacterial microbiota and obesity

I.J. Schalk Clinical Microbiology and Infection

R. Colodner, O. Nitzan, B. Chazan, H. Edelstein, R. Raz

Economic evaluation of vaccination: capturing the full benefits, with an application to human papillomavirus T. Bärnighausen, D.E. Bloom, E.T. Cafiero,

C-reactive protein as a marker of infection in critically ill patients

An evaluation of clinical stability criteria to predict hospital course in community-acquired pneumonia A.R. Akram, J.D. Chalmers, J.K. Taylor, J. Rutherford,

Migrant health—a cause for concern?

Penetration of fusidic acid and rifampicin into cerebrospinal fluid in low-grade inflammatory meningitis caused by Staphylococcus epidermidis A. Hedberg,

J. M. Pereira, R. P. Moreno, R. Matos, A. Rhodes, I. Martin-Loeches, M

J. M. Pereira, R. P. Moreno, R. Matos, A. Rhodes, I. Martin-Loeches, M

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

J.-P. Van geertruyden Clinical Microbiology and Infection

Virological tools to diagnose and monitor hepatitis C virus infection

R. Cantón Clinical Microbiology and Infection

A. Domínguez-Gil Hurlé, A. Sánchez Navarro, M.J. García Sánchez

Louis Pasteur, from crystals of life to vaccination

How to evaluate and predict the ecologic impact of antibiotics: the pharmaceutical industry view from research and development R. Bax Clinical Microbiology.

Chlamydia trachomatis infections in heterosexuals attending sexually transmitted disease clinics in Slovenia D. Kese, M. Maticic, M. Potocnik Clinical.

Increased incidence of nitroimidazole-refractory giardiasis at the Hospital for Tropical Diseases, London: 2008–2013 L.E.B. Nabarro, R.A. Lever, M. Armstrong,

Potential risk factors for infection with Candida spp

How to evaluate and predict the epidemiologic impact of antibiotic use in humans: the pharmacoepidemiologic approach D. Guillemot Clinical Microbiology.

J. Gonçalves-Pereira, A. Martins, P. Póvoa

Impact of infection on admission and of the process of care on mortality of patients admitted to the Intensive Care Unit: the INFAUCI study J. Gonçalves-Pereira,

Impact of antibiotic restrictions: the pharmaceutical perspective

Vector control: a cornerstone in the malaria elimination campaign

J. Logar, B. Šoba, T. Premru-Sršen, Ž. Novak-Antolič

Training for the infectious diseases speciality in Norway

Evaluation of the effect of appropriate antimicrobial therapy on mortality associated with Acinetobacter nosocomialis bacteraemia S.-C. Kuo, Y.-T. Lee,

R. Karakus, K. Caglar, C. Aybay Clinical Microbiology and Infection

B. Gordts Clinical Microbiology and Infection

Laboratory diagnosis and biosafety issues of biological warfare agents

CMI editorial report 2011 Clinical Microbiology and Infection

Effects of gentamicin monotherapy for the initial treatment of community-onset complicated non-obstructive acute pyelonephritis due to Enterobacteriaceae.

Elements of design: the knowledge on which we build

Changes in macrolide resistance among respiratory pathogens after decreased erythromycin consumption in Taiwan P.-R. Hsueh, J.-M. Shyr, J.-J. Wu Clinical.

Levofloxacin in the treatment of ventilator-associated pneumonia

Metagenomics and probiotics

B. Sádaba, J.R. Azanza, M.A. Campanero, E. García-Quetglas

Previously unknown species of Aspergillus

Laboratory diagnosis of Clostridium difficile disease

W.A. Craig Clinical Microbiology and Infection

Voriconazole concentrations and outcome of invasive fungal infections

Recent developments in staphylococcal scalded skin syndrome

Abstracts cont. Clinical Microbiology and Infection

Training in infectious diseases and tropical medicine in Britain

Fibronectin concentrations in catheter sepsis

Clinical infection services—the Leiden experience

An after-hours clinical liaison blood culture service—is it worth it?

Statin use and clinical outcomes among pneumonia patients

Overview of cefixime use in community-acquired infections

K. Kaier, N.T. Mutters, U. Frank Clinical Microbiology and Infection

F.J. Pastor, J. Guarro Clinical Microbiology and Infection

The atypical pneumonias: clinical diagnosis and importance

J.J. Keller, M.-C. Tsai, C.-C. Lin, Y.-C. Lin, H.-C. Lin

Outcome of prosthetic knee-associated infection: evaluation of 40 consecutive episodes at a single centre R.R. Laffer, P. Graber, P.E. Ochsner, W. Zimmerli

Serum ferritin levels in West Nile encephalitis

Modelling during an emergency: the 2009 H1N1 influenza pandemic

B.A. Cunha Clinical Microbiology and Infection

J.L. Balcázar Clinical Microbiology and Infection

G.C. Schito Clinical Microbiology and Infection

Community-acquired acute bacterial meningitis in the elderly in Turkey

Bloodstream infections as a marker of community-acquired sepsis severity. Results from the Portuguese community-acquired sepsis study (SACiUCI study)

Impact of antibiotic restrictions: the patient's perspective

Comparative study of pediculicidal effect of medical plants

CMI readers' survey Clinical Microbiology and Infection

The future of diagnostic bacteriology

Presentation transcript:

Pharmacokinetics of gentamicin in critically ill patients: pilot study evaluating the first dose J. Gonçalves-Pereira, A. Martins, P. Póvoa Clinical Microbiology and Infection Volume 16, Issue 8, Pages 1258-1263 (August 2010) DOI: 10.1111/j.1469-0691.2009.03074.x Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Relationship between gender and Vd/kg of gentamicin. Women have a significantly higher Vd/kg. Clinical Microbiology and Infection 2010 16, 1258-1263DOI: (10.1111/j.1469-0691.2009.03074.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Time course of gentamicin concentrations on the first day of therapy, assuming a one-compartment pharmacokinetic model and first-order elimination kinetics. The coefficients of variation of Cmax and trough concentration were 0.24 and 1.22, respectively. Target Cmax range is defined by the solid lines (16–24 mg/L). Clinical Microbiology and Infection 2010 16, 1258-1263DOI: (10.1111/j.1469-0691.2009.03074.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions