Loss of OCTR‐1 signalling enhances the activation of XBP‐1‐mediated UPR pathway. Loss of OCTR‐1 signalling enhances the activation of XBP‐1‐mediated UPR.

Slides:

Advertisements

Similar presentations

Effects of inhibiting inflammatory cell recruitment on fracture healing Treatment with CCR2 antagonist, INCB3344, led to impaired fracture healing compared.

Advertisements

Validating Cdk‐dependent chromatin association changes of selected outliers A–EValidation of changes in chromatin affinity following Cdk inhibition of.

GFP‐Sed5p localization defect in sgt2Δ.

Statistical analysis of transgene expression in pigs generated by lentiviral gene transfer. Statistical analysis of transgene expression in pigs generated.

Loss of Hdac3 impairs Ar signaling in mouse prostate tissues and has no effect on apoptosis Loss of Hdac3 impairs Ar signaling in mouse prostate tissues.

Activation of EphB4 by ephrinB2‐Fc prevents aberrant angiogenesis

Reduced astrocyte proliferation results in increased immune cell infiltration into the injured GM Reduced astrocyte proliferation results in increased.

Reduced scar formation in the injured GM of CCR2−/− mice

MOSPD2 is an ER‐resident protein able to tether synthetic vesicles by binding the FFAT motif MOSPD2 is an ER‐resident protein able to tether synthetic.

Colocalization of the human trimethylguanosine synthase 1 and survival of motor neuron proteins. Colocalization of the human trimethylguanosine synthase.

Surface distribution of immunogold‐labelled PS I (A–C) and ATP synthase (D–F) complexes. Surface distribution of immunogold‐labelled PS I (A–C) and ATP.

Analysis of the effect of loss of Brca2 on in vivo somatic mutation frequency and mutation type. Analysis of the effect of loss of Brca2 on in vivo somatic.

Cdc42.GTP directly activates PAK4.

Yeast Tgl3p expressed in HeLa cells localizes to lipid droplets.

SERCA2 is a functional adaptor for the alternative toll‐like receptor 9 (TLR9) signalling in cardiomyocytes Co‐immunoprecipitated TLR9 with SERCA2 antibody.

Dynamics of ookinete to oocyst transition, and effects of SRPN2 knockdown. Dynamics of ookinete to oocyst transition, and effects of SRPN2 knockdown. Mosquitoes.

Double‐stranded RNA binding of NS3 is required for HIV‐1 Tat complementation. Double‐stranded RNA binding of NS3 is required for HIV‐1 Tat complementation.

Optical labelling by two‐photon excitation.

Inhibition of XBP‐1‐mediated UPR suppresses the enhanced resistance to Pseudomonas aeruginosa infection of octr‐1(ok371) animals. Inhibition of XBP‐1‐mediated.

Dual Modes of Cdc42 Recycling Fine-Tune Polarized Morphogenesis

The activation of caspase‐3 and depolarization of the mitochondrial inner membrane are very rapid and occur in parallel. The activation of caspase‐3 and.

SncRNA715 regulates MBP translation.

Data analysis of thermal proteome profiling

Overexpression of RNase H1 decreases the induction of phosphorylated H2AX in post‐mitotic cells in response to topoisomerase 1 cleavage complexes. Overexpression.

The activity of ISWI is crucial when Wingless signalling is compromised in the wing and eye of Drosophila. salE‐Gal4 drove the expression of (A) UAS‐GFP,

AβOs bind to and impact hypothalamic neurons Representative immunocytochemistry images of mature hypothalamic neurons in culture exposed to vehicle (Veh)

NoRC regulates telomeric heterochromatin.

Dynamics of cell–cell repulsion regulated by PYK2 localized at focal adhesions in migrating cells. Dynamics of cell–cell repulsion regulated by PYK2 localized.

VAP‐A is recruited to interorganelle contact sites together with MOSPD2 VAP‐A is recruited to interorganelle contact sites together with MOSPD2 AHeLa cells.

cuf2Δ and fzr1Δ cells show a defect in meiotic termination.

Enhancement of basal mitophagy by USP30 depletion is dependent on PINK1 Enhancement of basal mitophagy by USP30 depletion is dependent on PINK1 Representative.

Crb reduces γ‐Secretase activity.

Fig. 4. Specific versus nonspecific NP accumulation.

Volume 5, Issue 5, Pages (December 2013)

KLK7 is involved in the Aβ degradation activity

Expression and occupancy of a set of transcription factors corresponding to the identified motifs at FAIRE peaks Expression and occupancy of a set of transcription.

MOSPD2 is a putative tail‐anchored protein

Beclin‐1 depletion reduces targeting of several outer kinetochore proteins. Beclin‐1 depletion reduces targeting of several outer kinetochore proteins.

Expression of GFP‐Aub transgenes in GSCs, and GSC loss phenotype in armi mutant Expression of GFP‐Aub transgenes in GSCs, and GSC loss phenotype in armi.

BAM3 is a CLE45 receptor BAM3 is a CLE45 receptor Schematic overview of the BAM3 gene structure. bam3 loss‐of‐function mutations that were isolated as.

Endogenous MOSPD2 is recruited to interorganelle contact sites by FFAT‐containing proteins Endogenous MOSPD2 is recruited to interorganelle contact sites.

FFAT motif‐dependent recruitment of MOSPD2 in ER–endosome contacts by STARD3NL FFAT motif‐dependent recruitment of MOSPD2 in ER–endosome contacts by STARD3NL.

Downregulation of human SSU72 results in telomere elongation and fragility Downregulation of human SSU72 results in telomere elongation and fragility Telomere.

Fibroblast proliferation and ECM changes during wound healing

The ER is the main source of cholesterol accumulated by STARD3 in endosomes The ER is the main source of cholesterol accumulated by STARD3 in endosomes.

Lipogenic genes and SREBP1 protein are upregulated in HF‐R

MOSPD2 silencing affects interorganelle contact sites organization

Comparison of proteomics and RNA‐Seq data.

NoRC suppresses recombination between telomeric repeats.

Cbl protein levels in ago3, twin, and armi mutant GSCs

Colocalization of microinjected miRNAs with PBs and cognate mRNA targets. Colocalization of microinjected miRNAs with PBs and cognate mRNA targets. (A)

Aub represses Cbl expression in the GSCs

Loss of tight junctions on Rac1 activation in mature cysts.

Fig. 2 ALRN-6924 rapidly increases transcription at the p21 locus and affects its bursting dynamics. ALRN-6924 rapidly increases transcription at the p21.

Protein interactions at the nuclear pore.

ZBTB48 is required for MTFP1 expression

Lipid presentation by CD11c+ cells controls iNKT cell subsets

Ubqln1 interacts with Ubqln4.

Mitochondrial occupancy decreases presynaptic Ca2+ signals

LXRα enhances glucose uptake and O‐GlcNAc signaling via activation of the hexosamine biosynthetic pathway (HBP) in cultured cardiomyocytes LXRα enhances.

PKAN human neurons show altered oxidative status

Structure, localization, and ER exit of RUSH reporter proteins.

In vitro interaction studies (related to Fig 2)‏

Effect of D‐Asp treatment on myelination and remyelination in cerebellar organotypic slices Effect of D‐Asp treatment on myelination and remyelination.

S100A1 and S100B mediate the suppression of terminal differentiation of chondrocytes by the SOX trio. S100A1 and S100B mediate the suppression of terminal.

(A) Observed significant protein fold‐changes during the fed–fasting transition in C57BL/6J (B6) and 129Sv (S9) mice fed with a normal diet (T0). (A) Observed.

Peri‐nuclear Rab34‐positive membranes contact lysosomes

RIF1 interacts with protein phosphatase 1 isoforms

Bevacizumab therapy leads to reduced vessel density and increased Ang‐2 expression Bevacizumab therapy leads to reduced vessel density and increased Ang‐2.

dex-1 expression in the seam cells is regulated by DAF-16.

Presentation transcript:

Loss of OCTR‐1 signalling enhances the activation of XBP‐1‐mediated UPR pathway. Loss of OCTR‐1 signalling enhances the activation of XBP‐1‐mediated UPR pathway. (A) Images of Phsp‐4::GFP(zcIs4) and octr‐1(ok371);Phsp‐4::GFP(zcIs4) 1‐day‐old animals exposed to Pseudomonas aeruginosa PA14. Animals that best represent the fluorescence level of the population were shown. (B). GFP quantification from Phsp‐4::GFP(zcIs4) and octr‐1(ok371);Phsp‐4::GFP(zcIs4) 1‐day‐old animals exposed to P. aeruginosa PA14. Binary mean intensity of the region of interest (ROI) that corresponds to an entire animal was measured by NIS‐Elements AR 3.2 software. N=10–20, error bars represent s.e.m. octr‐1(ok371);Phsp‐4::GFP(zcIs4) versus Phsp‐4::GFP(zcIs4) on PA14: P<0.05. (C) GFP fluorescence intensity (FLU‐2) of Phsp‐4::GFP(zcIs4) and octr‐1;Phsp‐4::GFP(zcIs4) 1‐day‐old animals exposed to P. aeruginosa was plotted against animal size, measured as time of flight (TOF). Each dot represents an individual animal. GFP, green fluorescent protein; UPR, unfolded protein response; XBP‐1, X‐box binding protein‐1. Jingru Sun et al. EMBO Rep. 2012;13:855-860 © as stated in the article, figure or figure legend