Lymphotoxins: New Targets for Hepatocellular Carcinoma

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Presentation transcript:

Lymphotoxins: New Targets for Hepatocellular Carcinoma Augusto Villanueva, Radoslav Savic, Josep M. Llovet Cancer Cell Volume 16, Issue 4, Pages 272-273 (October 2009) DOI: 10.1016/j.ccr.2009.09.012 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Potential Targets of Prevention and Treatment of Hepatocellular Carcinoma Viral hepatitis and alcohol abuse are the main risk factors for developing chronic liver inflammation leading to advanced fibrosis and cirrhosis. Once advanced fibrosis has been established, evidence suggests the implication of inflammatory signals and growth factor cascades in the development of HCC. In this setting, chemoprevention strategies are expected to target key pro-oncogenic molecules. In established HCC, the molecular classification of the tumors would allow targeting specific pathways and oncogenic loops in a more personalized manner. Cancer Cell 2009 16, 272-273DOI: (10.1016/j.ccr.2009.09.012) Copyright © 2009 Elsevier Inc. Terms and Conditions