Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value by Saman.

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Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value by Saman Abbas, Sanne Lugthart, François G. Kavelaars, Anita Schelen, Jasper E. Koenders, Annelieke Zeilemaker, Wim J. L. van Putten, Anita W. Rijneveld, Bob Löwenberg, and Peter J. M. Valk Blood Volume 116(12):2122-2126 September 23, 2010 ©2010 by American Society of Hematology

Survival analyses of patients with AML with or without IDH1 and IDH2 mutations. Survival analyses of patients with AML with or without IDH1 and IDH2 mutations. (A) Kaplan-Meier estimates of OS for all AML patients. (B) OS for AML patients with normal karyotypes. (C) OS for patients with intermediate-risk AML and FLT3mutant and NPM1mutant. (D) OS for patients with intermediate-risk AML and FLT3wild-type and NPM1mutant. (E) OS for patients with intermediate-risk AML and FLT3wild-type and NPM1wild-type. (F) EFS for patients with intermediate-risk AML and FLT3wild-type and NPM1wild-type. Survival curves in red represent cases with IDH1mutant; those in green, IDH2mutant; and those in black, cases with IDH1wild-type and IDH2wild-type, respectively. The log-rank P value is indicated per Kaplan-Meier analysis. Saman Abbas et al. Blood 2010;116:2122-2126 ©2010 by American Society of Hematology