Hugh B. Fackrell filename : Kuby 01B7 Acquired Immunity Hugh B. Fackrell filename : Kuby 01B7

Acquired Immunity: Outline Acquired vs Innate Immunity Functions of Acquired Immunity Humoral Immunity: antibody Cell Mediated Immunity Role of Macrophages Regulation of Immunity Next

Acquired Immunity: Definitions Antigen Immunogen Humoral Immunity Cell Mediated Immunity Next

Acquired Immunity: Objectives Define the following terms: Antigen, immunogen, acquired immunity, humoral immunity, cell mediated immunity Identify the cells of the acquired immune response from light or electron micrographs Identify the functions of the cells of the acquired immune reponse Next

Acquired Immunity Definition Characteristics Acquired immunity( AKA adaptive immunity) is an altered reactivity to a specific compound after exposure to that compound Characteristics Specificity Memory Next

Acquired Immunity Important Features The altered reactivity will not be to all compounds, just those compounds to which the animal has been exposed The animal has a heightened specific response on second and subsequent exposures because the body ” remembers” previous contacts Next

Functions of Acquired Immunity Discriminate between self and non self for: Defense destruction of foreign molecules Homeostasis removal of dead or damaged cells Surveillance control of mutant or cancer cells Next

Acquired Immunity has Two Forms Humoral Immunity lymphocytes react INDIRECTLY on non self molecules via antibodies Cell Mediated Immunity Lymphocytes act DIRECTLY on the non self molecules Next

Lymphocytes

combines with products Immunogen vs Antigen ANTIGEN: combines with the products of an immune response IMMUNOGEN: triggers immunity and combines with products

Antigen: interaction

Remember Immunogenicity is not an inherent characteristic of a molecule Immunogen MUST first be recognized as foreign by the body Next

Adaptive vs Innate Immunity

Primary vs Secondary Responses

Humoral Immunity

Antibodies Distinguish Between Diseases measles & mumps Macromolecules proteins, complex carbohydrates Molecules amino acids, sugars Submolecular Structures D& L isomers; ortho, meta, para positions Next

B cell blasts

B Cell Transformation

Clonal Selection: B cells

Immunglobulin on B cells

Plasma cell function

Antibody: a Flexible mediator

Plasma cell: function

Complement functions

Cell Mediated Immunity

T cell blasts

T cell blasts: structure

T cells

Cell mediated clonal selection

T cell transformation

T cells ANAE stain

Role of Macrophages

Monocyte

Monocyte structure

Macrophage Activation products

Macrophages & T cells

T cells interacting with Macrophage

Macrophage mediatiors: CD14 receptor

Macrophage mediators: CD14 & LPS receptors

Endotoxin induction of Macrophage mediators: direct induction

Oponsization: mechanisms

Regulation of Immunity

Range of immune responses

Antigen Processing

Cellular interactions during the humoral response

A Complete Immune Response Lymphocytes B cells T cells Macrophages critical accessory cells Complement combines with antibody to enhance destruction Next

White Blood Cells

Adverse effects of Immunity

The End

Acquired Immunity: Questions How does clonal selection contribute to memory in the immune response? Name three feature of a secondary immune response that make it different from a primary immune response.

Questions(1) Interleukin 2 is a nonspecific growth factor that stimulates the growth of TH cells during the immune response. In view of this nonspecificity of IL-2, what mechanism assures that only TH cells specific for a given antigen proliferate and that all other TH cells do not proliferate

Questions (2) Antigen presenting cells play a role in both humoral and cell mediated immune responses Name three type af antigen presenting cells Which class of MHC molecules are expressed on the membrane of antigen presenting cells? Which lymphocytes interact eith antigen presenting cells?