A. Pierro, S. Ficarelli, N. Ayhan, S. Morini, L. Raumer, M

Slides:

Advertisements

Similar presentations

Models for the organisation of hospital infection control and prevention programmes B. Gordts Clinical Microbiology and Infection Volume 11, Pages

Advertisements

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

P.-Y. Lévy Clinical Microbiology and Infection

Twelve years of dengue surveillance in Belgian travellers and significant increases in the number of cases in 2010 and 2013 J. Verschueren, L. Cnops,

C. Steininger, M. Redlberger, W. Graninger, M. Kundi, T. Popow-Kraupp

Evaluation of a commercial IgE ELISA in comparison with IgA and IgM ELISAs, IgG avidity assay and complement fixation for the diagnosis of acute toxoplasmosis

High sensitivity and specificity of the C6-peptide ELISA on cerebrospinal fluid in Lyme neuroborreliosis patients N.D. van Burgel, A. Brandenburg, H.J.

Human papilloma viruses and cancer in the post-vaccine era

I.J. Schalk Clinical Microbiology and Infection

Incidence and outcome of Staphylococcus aureus endocarditis—a 10-year single-centre northern European experience H. Asgeirsson, A. Thalme, M. Kristjansson,

D. Khalil, M. Hultin, M.U. Rashid, B. Lund

C.-P. Kuo, C.-L. Wu, H.-T. Ho, C.G. Chen, S.-I. Liu, Y.-T. Lu

Cross-reaction between Yersinia outer membrane proteins and anti-Borreli antibodies in sera of patients with Lyme disease E. Golkocheva-Markova, I. Christova,

Risk factors for cryptococcal infection among patients with rheumatoid arthritis receiving different immunosuppressive medications T.-L. Liao, Y.-M.

Migrant health—a cause for concern?

Three-year retrospective analysis of the incidence of Toxoplasma gondii infection in pregnant women living in the Greater Romagna Area (northeastern Italy)

C.-S. Lee, J.-H. Lee Clinical Microbiology and Infection

Emerging issues on hepatitis C virus infection after the introduction of the Directly Acting Antivirals G. Ippolito Clinical Microbiology and Infection

J.-P. Van geertruyden Clinical Microbiology and Infection

Imported cases of dengue virus infection: Emilia-Romagna, Italy, 2010

A serosurvey of Orientia tsutsugamushi from patients with scrub typhus

Hepatitis B and C virus-related carcinogenesis

Virological tools to diagnose and monitor hepatitis C virus infection

Dynamics of serum procalcitonin in patients after major neurosurgery

Refugee crisis and re-emergence of forgotten infections in Europe

A. Pierro, S. Ficarelli, N. Ayhan, S. Morini, L. Raumer, M

Performance of Focus ELISA tests for herpes simplex virus type 1 (HSV-1) and HSV-2 antibodies among women in ten diverse geographical locations R. Ashley-Morrow,

Detection of specific antibodies against West Nile and Usutu viruses in healthy blood donors in northern Italy, 2010–2011 A. Pierro, P. Gaibani, C. Spadafora,

Increased incidence of nitroimidazole-refractory giardiasis at the Hospital for Tropical Diseases, London: 2008–2013 L.E.B. Nabarro, R.A. Lever, M. Armstrong,

Should standardized susceptibility testing for microbial biofilms be introduced in clinical practice? T. Coenye, D. Goeres, F. Van Bambeke, T. Bjarnsholt

Prevalence of Toscana virus antibodies in residents of Croatia

Vector control: a cornerstone in the malaria elimination campaign

Prevalence of antibodies to phleboviruses within the sand fly fever Naples virus species in humans, northern Greece V. Anagnostou, A. Papa Clinical.

High prevalence of early childhood infection by Kaposi's sarcoma-associated herpesvirus in a minority population in China Y. Cao, V. Minhas, X. Tan,

Good epidemiological practice: a narrative review of appropriate scientific methods to evaluate the impact of antimicrobial stewardship interventions

Estimation of delay in detecting hepatitis C virus antibodies in pools compared to individual testing on seroconversion panels B. Sarov, L. Novack, N.

R. Karakus, K. Caglar, C. Aybay Clinical Microbiology and Infection

Performance of hepatitis C virus (HCV) direct-acting antivirals in clinical trials and daily practice J.E. Arends, P.A.M. Kracht, A.I.M. Hoepelman Clinical.

I. Al Shukri, F. Hamilton, M. Evans, S. Cooper, G. McKenzie, L

Metagenomics and probiotics

Hepatitis B and C virus-related carcinogenesis

Previously unknown species of Aspergillus

Sexually acquired Zika virus: a systematic review

Interference between respiratory syncytial virus and rhinovirus in respiratory tract infections in children S. Karppinen, L. Toivonen, L. Schuez-Havupalo,

Systematic review of antibiotic consumption in acute care hospitals

Imported cases of dengue virus infection: Emilia-Romagna, Italy, 2010

N. Jazmati, M. Hellmich, B. Ličanin, G. Plum, A.J. Kaasch

Testing patients with non-specific symptoms for antibodies against Borrelia burgdorferi sensu lato does not provide useful clinical information about.

Evaluation of eight commercial tests for Mycoplasma pneumoniae antibodies in the absence of acute infection R. Nir-Paz, A. Michael-Gayego, M. Ron, C.

Correlation of higher antibody levels to pneumococcal proteins with protection from pneumococcal acute otitis media but not protection from nasopharyngeal.

Accurate hepatitis C virus genotyping and selection of optimal therapy: lessons from a St Petersburg strain infection E. Knops, E. Heger Clinical Microbiology.

Vaccinations against respiratory tract infections at Hajj

C. Alkan, A. B. Allal-Ikhlef, S. Alwassouf, A. Baklouti, G

Increasing numbers of hospitalizations and deaths with mention of Clostridium difficile infection, north-eastern Italy, 2008–2013 U. Fedeli, E. Schievano,

Statin use and clinical outcomes among pneumonia patients

Detection of IgA and low-avidity IgG antibodies for the diagnosis of recent active toxoplasmosis José Gutiérrez, María Rodríguez, Gonzalo Piédrola, María.

Survival of rhinoviruses on human fingers

Outcome of prosthetic knee-associated infection: evaluation of 40 consecutive episodes at a single centre R.R. Laffer, P. Graber, P.E. Ochsner, W. Zimmerli

Genomic diversity of group A rotavirus strains in patients aged 1–36 months admitted for acute watery diarrhoea in northern India: a hospital-based study

Virology: a scientific discipline facing new challenges

Serum antibodies against Panton–Valentine leukocidin in a normal population and during Staphylococcus aureus infection M. Croze, O. Dauwalder, O. Dumitrescu,

Serum ferritin levels in West Nile encephalitis

Modelling during an emergency: the 2009 H1N1 influenza pandemic

Quantitative real-time PCR and the (1 → 3)-β-d-glucan assay for differentiation between Pneumocystis jirovecii pneumonia and colonization Y. Matsumura,

J.L. Balcázar Clinical Microbiology and Infection

Impact of source of infection and vancomycin AUC0–24/MICBMD targets on treatment failure in patients with methicillin-resistant Staphylococcus aureus.

Impact of antibiotic restrictions: the patient's perspective

L. Bichaud, R. P. Piarroux, A. Izri, L. Ninove, C. Mary, X

CMI readers' survey Clinical Microbiology and Infection

The future of diagnostic bacteriology

Presentation transcript:

Characterization of antibody response in neuroinvasive infection caused by Toscana virus A. Pierro, S. Ficarelli, N. Ayhan, S. Morini, L. Raumer, M. Bartoletti, A. Mastroianni, F. Prati, S. Schivazappa, P. Cenni, C. Vocale, G. Rossini, P. Gaibani, V. Sambri, M.P. Landini, R.E. Lewis, R.N. Charrel, S. Varani Clinical Microbiology and Infection Volume 23, Issue 11, Pages 868-873 (November 2017) DOI: 10.1016/j.cmi.2017.03.017 Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Specific antibody development in TOSV infected patients. Anti-TOSV IgM (a) and IgG (b) antibody development in 41 patients with acute TOSV infection is represented in box-and-whisker plots. Log10 IgG median and interquartile range; vertical lines represent minimum and maximum values. ND, not detected. Clinical Microbiology and Infection 2017 23, 868-873DOI: (10.1016/j.cmi.2017.03.017) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 TOSV-IgG avidity index (AI). Maturation of anti-TOSV IgG during the 600 days of study. The AI increased over the first month of infection until a plateau by Day 180, then decreased to low values by Day 600. Data points represent median values plus 95% CI for median. Clinical Microbiology and Infection 2017 23, 868-873DOI: (10.1016/j.cmi.2017.03.017) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 TOSV IgG maturation. AI was not influenced by patients' gender (a) and age (b), but was higher in patients with meningoencephalitis at Day 30 and Day 90 post infection (c). Data points represent median values plus 95% CI for median. Clinical Microbiology and Infection 2017 23, 868-873DOI: (10.1016/j.cmi.2017.03.017) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 4 TOSV neutralization assay. 210 sera were tested for TOSV MN assay and 187 were TOSV reactive with moderate neutralizing titre. Log10 median and interquartile range; vertical lines represent minimum and maximum values. Clinical Microbiology and Infection 2017 23, 868-873DOI: (10.1016/j.cmi.2017.03.017) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. S1. Specific IgM and IgG titre is not dependent on age, gender, or disease severity in TOSV infected patients. Anti-TOSV IgM (a, c, e) and IgG (b, d, f) antibody titres in 41 patients with acute TOSV infection segregated on the basis of age (a, b), gender (c, d), and disease severity (e, f). IgG median±95% CI. Clinical Microbiology and Infection 2017 23, 868-873DOI: (10.1016/j.cmi.2017.03.017) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions