Development and Initial Validation of a Questionnaire to Measure Health-Related Quality of Life of Adults with Common Variable Immune Deficiency: The.

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Development and Initial Validation of a Questionnaire to Measure Health-Related Quality of Life of Adults with Common Variable Immune Deficiency: The CVID_QoL Questionnaire Isabella Quinti, MD, PhD, Federica Pulvirenti, MD, Patrizia Giannantoni, Stat PhD, Joud Hajjar, MD, Debra L. Canter, MS, Cinzia Milito, MD, PhD, Damiano Abeni, MD, Jordan S. Orange, MD, PhD, Stefano Tabolli, MD The Journal of Allergy and Clinical Immunology: In Practice Volume 4, Issue 6, Pages 1169-1179.e4 (November 2016) DOI: 10.1016/j.jaip.2016.07.012 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Study design to develop and validate a questionnaire to measure health-related quality of life of adults with common variable immune deficiency. BMI, Body mass index; CVID, common variable immune deficiencies; EQ-5D, EuroQol-5 dimensions questionnaire; GHQ-12, Global Health Questionnaire; PAD, primary antibody deficiency; PtGA, patient global assessment; QoL, quality of life; SF-36, Short Form 36 questionnaire; SGRQ, Saint George Respiratory Questionnaire; TL, IgG trough level. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, 1169-1179.e4DOI: (10.1016/j.jaip.2016.07.012) Copyright © 2016 The Authors Terms and Conditions

Figure 2 CVID_QoL dimensions identified by factor analysis. Each item is indicated as the number of the question, followed by an indicative word summarizing the sentence, that is, 1 Sadness = question number 1: I felt sad. CVID, Common variable immune deficiency; EF, emotional functioning, GSS, gastrointestinal and skin symptoms; QoL, quality of life; RF, relational functioning. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, 1169-1179.e4DOI: (10.1016/j.jaip.2016.07.012) Copyright © 2016 The Authors Terms and Conditions

Figure 3 Distribution of the 118 CVID_QoL Global scores. Patients were grouped according to their CVID_QoL Global score. CVID, Common variable immune deficiency; QoL, quality of life. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, 1169-1179.e4DOI: (10.1016/j.jaip.2016.07.012) Copyright © 2016 The Authors Terms and Conditions

Figure 4 Number of infections and CVID_QoL scores. Patient groups were selected according to the number of self-reported episodes of infections in the 3 (A) and in the 12 months (B) preceding the study time. P values were calculated using the t-test and ANOVA. CVID, Common variable immune deficiency; EF, emotional functioning; GSS, gastrointestinal and skin symptoms; QoL, quality of life; RF, relational functioning. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, 1169-1179.e4DOI: (10.1016/j.jaip.2016.07.012) Copyright © 2016 The Authors Terms and Conditions

Figure E1 The Italian version of the CVID_QoL questionnaire. CVID, Common variable immune deficiency; QoL, quality of life. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, 1169-1179.e4DOI: (10.1016/j.jaip.2016.07.012) Copyright © 2016 The Authors Terms and Conditions

Figure E1 The Italian version of the CVID_QoL questionnaire. CVID, Common variable immune deficiency; QoL, quality of life. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, 1169-1179.e4DOI: (10.1016/j.jaip.2016.07.012) Copyright © 2016 The Authors Terms and Conditions

Figure E2 The English version of the CVID_QoL questionnaire. CVID, Common variable immune deficiency; QoL, quality of life. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, 1169-1179.e4DOI: (10.1016/j.jaip.2016.07.012) Copyright © 2016 The Authors Terms and Conditions

Figure E2 The English version of the CVID_QoL questionnaire. CVID, Common variable immune deficiency; QoL, quality of life. The Journal of Allergy and Clinical Immunology: In Practice 2016 4, 1169-1179.e4DOI: (10.1016/j.jaip.2016.07.012) Copyright © 2016 The Authors Terms and Conditions