An Activation Marker Finds a Function Diana M. Mitchell, Matthew A. Williams  Immunity  Volume 32, Issue 1, Pages 9-11 (January 2010) DOI: 10.1016/j.immuni.2010.01.003 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 CD44 Prevents Fas-Mediated Apoptosis during Th1 Cell Clonal Expansion After activation in response to influenza infection, Th1 cells upregulate CD44, overcome Fas-induced death signals, undergo clonal expansion, and populate the memory pool after pathogen clearance. In the absence of CD44 signals, clonally expanding T cells undergo Fas-mediated apoptosis and fail to progress to the memory cell pool. Immunity 2010 32, 9-11DOI: (10.1016/j.immuni.2010.01.003) Copyright © 2010 Elsevier Inc. Terms and Conditions