Joseph E. Druso, Claudia Fischbach Trends in Cancer

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Biophysical Properties of Extracellular Matrix: Linking Obesity and Cancer Joseph E. Druso, Claudia Fischbach Trends in Cancer Volume 4, Issue 4, Pages 271-273 (April 2018) DOI: 10.1016/j.trecan.2018.02.001 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Obese Tissue Extracellular Matrix (ECM) Induces Invasive Traits in Breast Cancer Cells. Obese tissue ECM is composed of stiffened, aligned fibers and high interstitial pressure, as compared to lean tissue ECM. These changes can lead to hypoxic conditions in obese tissues, as well as increased myofibroblast and macrophage content which further contribute toward the inflamed, fibrotic ECM phenotype. Breast cancer cell responses to obese ECM include upregulation of invasive characteristics that may result in higher rates of metastases, thus providing intriguing therapeutic intervention points. Trends in Cancer 2018 4, 271-273DOI: (10.1016/j.trecan.2018.02.001) Copyright © 2018 Elsevier Inc. Terms and Conditions