C. Vollmer, S. Weiß, C. Beck, I. Bauer, O. Picker

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Hypothermia improves oral and gastric mucosal oxygenation during hypoxic challenges C. Vollmer, S. Weiß, C. Beck, I. Bauer, O. Picker British Journal of Anaesthesia Volume 113, Issue 3, Pages 433-442 (September 2014) DOI: 10.1093/bja/aet462 Copyright © 2014 The Author(s) Terms and Conditions

Fig 1 Experimental protocol: hypoxia during normothermia (HPX), hypoxia during hypothermia (HT/HPX), hypoxia during hypothermia with glibenclamide (HT/Glib/HPX), and hypoxia during hypothermia with levosimendan (HT/Levo/HPX). British Journal of Anaesthesia 2014 113, 433-442DOI: (10.1093/bja/aet462) Copyright © 2014 The Author(s) Terms and Conditions

Fig 2 Effect of hypoxia (HPX), hypoxia during hypothermia (HT/HPX), hypoxia during hypothermia with glibenclamide (HT/Glib/HPX), and hypoxia during hypothermia with levosimendan (HT/Levo/HPX) on gastric and oral microvascular haemoglobin oxygen saturation (μHbO2). Data are presented as absolute changes zero referenced before hypoxia vs μHbO2 during hypoxia for n=5 dogs, mean (sem), *P<0.05, Fisher's PLSD. British Journal of Anaesthesia 2014 113, 433-442DOI: (10.1093/bja/aet462) Copyright © 2014 The Author(s) Terms and Conditions

Fig 3 Cardiac output in the four experimental groups over time. Data are presented as absolute values for n=5 dogs, mean (sem), *P<0.05 vs Group HT/Levo/HPX during hypoxia. British Journal of Anaesthesia 2014 113, 433-442DOI: (10.1093/bja/aet462) Copyright © 2014 The Author(s) Terms and Conditions

Fig 4 Effect of hypoxia (HPX), hypoxia during hypothermia (HT/HPX), hypoxia during hypothermia with glibenclamide (HT/Glib/HPX), and hypoxia during hypothermia with levosimendan (HT/Levo/HPX) on (a) oral mucosal perfusion (μflow), (b) oxygen delivery (μDO2), and (c) oxygen consumption (VO2). Data are presented as absolute changes zero referenced before hypoxia vs the same variable during hypoxia for n=5 dogs, mean (sem). British Journal of Anaesthesia 2014 113, 433-442DOI: (10.1093/bja/aet462) Copyright © 2014 The Author(s) Terms and Conditions