Gut matters: Microbe-host interactions in allergic diseases

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Presentation transcript:

Gut matters: Microbe-host interactions in allergic diseases Gabriele Hörmannsperger, PhD, Thomas Clavel, PhD, Dirk Haller, PhD Journal of Allergy and Clinical Immunology Volume 129, Issue 6, Pages 1452-1459 (June 2012) DOI: 10.1016/j.jaci.2011.12.993 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Oral tolerance mechanisms. Innocuous antigens that enter mucosal tissues through organized antigen sampling of M cells in PPs or lamina propria DCs induce tolerogenic mechanisms on antigen presentation. The tolerogenic microenvironment in the mucosal tissue and PPs primes antigen-presenting cells toward reduced antigen responsiveness, resulting either in clonal deletion of antigen-specific T cells through induction of T-cell anergy or apoptosis or the induction of antigen-specific Treg cells on antigen presentation in PPs or MLNs. These Treg cells are subsequently systemically distributed through the bloodstream and enter both mucosal and peripheral tissues, where they can exert anti-inflammatory activities on antigen contact. The induction of IgA-secreting plasma cells contributes to the induction of oral tolerance because IgA not only plays an important role in immune exclusion of antigens but also contributes to mucosal antigen sampling and anti-inflammatory antigen neutralization. IEC, Intestinal epithelial cells; LP, lamina propria; MP, macrophage; PGE2, prostaglandin E2. Journal of Allergy and Clinical Immunology 2012 129, 1452-1459DOI: (10.1016/j.jaci.2011.12.993) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Systemic immune homeostasis depends on intestinal microbe-host interactions. Under the influence of genetic and environmental factors, the activity and antigenic potential of gut microorganisms have a strong influence on barrier maintenance, the development of gut-associated lymphoid tissues, and eventually systemic immune responses. LTA, Lipoteichoic acid; PSA, polysaccharide A; redox, redox potential. Journal of Allergy and Clinical Immunology 2012 129, 1452-1459DOI: (10.1016/j.jaci.2011.12.993) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions