Toxic epidermal necrolysis in the absence of circulating T cells: A possible role for resident memory T cells Hisato Iriki, MD, Takeya Adachi, MD, Mariko.

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Presentation transcript:

Toxic epidermal necrolysis in the absence of circulating T cells: A possible role for resident memory T cells Hisato Iriki, MD, Takeya Adachi, MD, Mariko Mori, MD, Keiji Tanese, MD, PhD, Takeru Funakoshi, MD, PhD, Daiki Karigane, MD, Takayuki Shimizu, MD, PhD, Shinichiro Okamoto, MD, PhD, Keisuke Nagao, MD, PhD Journal of the American Academy of Dermatology Volume 71, Issue 5, Pages e214-e216 (November 2014) DOI: 10.1016/j.jaad.2014.07.013 Copyright © 2014 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Toxic epidermal necrolysis. A, Clinical presentation on day 30 after initial chemotherapy. Skin lesions on the back showed exudative erythema with positive Nikolsky sign. B, Histopathologic findings of skin biopsy specimen taken from area of erythema on the left arm. Hematoxylin-eosin staining showed interface dermatitis and exocytosis of mononuclear cells with individual cell necrosis of keratinocytes. Scale bar: 300 μm. Journal of the American Academy of Dermatology 2014 71, e214-e216DOI: (10.1016/j.jaad.2014.07.013) Copyright © 2014 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 A to D, Two-color immunofluorescence images of frozen skin sections from the left arm were obtained for CD4/CD8 (green) and CD45RO/CD69 (red). The majority of CD4+ T cells and CD8+ T cells are costained with CD45RO and CD69. T cells that co-express both molecules (arrowheads). Scale bars: 20 μm. Journal of the American Academy of Dermatology 2014 71, e214-e216DOI: (10.1016/j.jaad.2014.07.013) Copyright © 2014 American Academy of Dermatology, Inc. Terms and Conditions