Cross-sectional and longitudinal study of the impact of posterior meniscus horn lesions on adjacent cartilage composition, patient-reported outcomes and.

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Cross-sectional and longitudinal study of the impact of posterior meniscus horn lesions on adjacent cartilage composition, patient-reported outcomes and gait biomechanics in subjects without radiographic osteoarthritis C. Russell, V. Pedoia, R.B. Souza, S. Majumdar Osteoarthritis and Cartilage Volume 25, Issue 5, Pages 708-717 (May 2017) DOI: 10.1016/j.joca.2016.10.025 Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Diagramed are the overall study design and subject selection criteria for the 15 subjects with meniscus lesions and their matched controls. Osteoarthritis and Cartilage 2017 25, 708-717DOI: (10.1016/j.joca.2016.10.025) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 In these 3D renderings, the average cartilage T1ρ for each group (n = 15, 15) is overlaid onto a bone mesh constructed from the first echo in the two figures on the left. Voxel-based statistics, such as the average percent difference (second from the right) and average P-value (right) are also imaged. The arrows point to the region of significant difference between the groups in the LT. Osteoarthritis and Cartilage 2017 25, 708-717DOI: (10.1016/j.joca.2016.10.025) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 In these 3D renderings, the average cartilage T1ρ for each group is overlaid onto a bone mesh constructed from the first echo in the top four images. The arrow points to the longitudinal difference in the MFC, which is present in the group with meniscal lesions, but not in the group without. Osteoarthritis and Cartilage 2017 25, 708-717DOI: (10.1016/j.joca.2016.10.025) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 In these 3D renderings, the average cartilage T2 for each group is overlaid onto a bone mesh constructed from the first echo in the top four images. The arrow points to the longitudinal difference in the MT, which is present in the group with meniscal lesions, but not in the group without. Osteoarthritis and Cartilage 2017 25, 708-717DOI: (10.1016/j.joca.2016.10.025) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Supplementary Fig. 5 A indicates a Pearson Correlation SPM of T1ρ with the KOOS QOL in the lesion group showing negative associations, thereby confirming simultaneous accelerated cartilage degeneration and worse PROMs in the lesion group. B indicates baseline and 2-year T1ρ maps of individual subjects, one of which drove the observed correlation of KOOS QOL and longitudinal T1ρ changes. Osteoarthritis and Cartilage 2017 25, 708-717DOI: (10.1016/j.joca.2016.10.025) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions