FNAIT: the fetus pleads guilty!

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Presentation transcript:

FNAIT: the fetus pleads guilty! by Cécile Kaplan Blood Volume 116(18):3384-3386 November 4, 2010 ©2010 by American Society of Hematology

FcRn a key factor in FNIT. (A) Fetal FcRn is required for FNIT FcRn a key factor in FNIT. (A) Fetal FcRn is required for FNIT. Low platelet counts are observed only in pups expressing fetal FcRn delivered from immunized β3−/−FcRn−/− × β3+/+FcRn−/+. FcRn a key factor in FNIT. (A) Fetal FcRn is required for FNIT. Low platelet counts are observed only in pups expressing fetal FcRn delivered from immunized β3−/−FcRn−/− × β3+/+FcRn−/+. (B) Anti-FcRn monoclonal antibody injection during pregnancy. Low platelet counts are observed only in pups delivered from nontreated immunized female mice. N = platelet counts. (Professional illustration by Paulette Dennis.)‏ Cécile Kaplan Blood 2010;116:3384-3386 ©2010 by American Society of Hematology