Volume 24, Issue 2, Pages (June 2017)

Slides:

Advertisements

Similar presentations

Garlic decreases liver and kidney receptor for advanced glycation end products expression in experimental diabetes Khaled K. Al-Qattan, Mohamed H. Mansour,

Advertisements

Influence of maternal nicotine exposure during gestation and lactation on lactate dehydrogenase isoenzyme profile and transcript levels in developing neonatal.

Immunopathological characterization of selected mouse models of inflammatory bowel disease: Comparison to human disease Yava L. Jones-Hall, Matthew B.

Extra-virgin olive oil diet and mild physical activity prevent cartilage degeneration in an osteoarthritis model: an in vivo and in vitro study on lubricin.

Extracellular superoxide dismutase increased the therapeutic potential of human mesenchymal stromal cells in radiation pulmonary fibrosis Li Wei, Jing.

Volume 24, Issue 3, Pages (September 2017)

Noha Abd ElRahim Aboulhagag, Rana Fathy Torky, Sabah Ahmed Fadel

Volume 24, Issue 2, Pages (June 2017)

Volume 24, Issue 3, Pages (September 2017)

Experimental Bronchiolitis Obliterans Induced by In Vivo HVJ-Liposome–Mediated Endothelin-1 Gene Transfer Shin-ichi Takeda, MD, Yoshiki Sawa, MD, Masato.

Volume 22, Issue 2, Pages (June 2015)

Schwann cell injuries of radial nerve after lead (Pb) exposure in rats

The role of lymphatic vessels in the heart

Rats exposed to 2.45GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3 Rini Varghese, Anuradha.

Volume 25, Issue 2, Pages (June 2018)

NF-κBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1β-induced and TNF-α-induced chondrocytes Dr C. Lianxu, Ph.D.,

Volume 24, Issue 4, Pages (December 2017)

Volume 21, Issue 3, Pages (September 2014)

Amelioration of pancreatic and renal derangements in streptozotocin-induced diabetic rats by polyphenol extracts of Ginger (Zingiber officinale) rhizome

Enteral supplementation of alanyl–glutamine attenuates the up-regulation of beta- defensin-2 protein in lung injury induced by intestinal ischemia reperfusion.

Tetrandrine prevents monocrotaline-induced pulmonary arterial hypertension in rats through regulation of the protein expression of inducible nitric oxide.

Ret mouse very large tumors (VLTs) display altered ratios of infiltrating memory to naive T cells: Roles in tumor expansion Mohammad W. Khan, Viktor.

Volume 18, Issue 2, Pages (April 2011)

Volume 24, Issue 4, Pages (December 2017)

Omega-3 fatty acids decreases oxidative stress, tumor necrosis factor-alpha, and interleukin-1 beta in hyperthyroidism-induced hepatic dysfunction rat.

Role of serotonin and nuclear factor-kappa B in the ameliorative effect of ginger on acetic acid-induced colitis Eman S.H. Abd Allah, Rania Makboul,

Ceftriaxone attenuates glutamate-mediated neuro-inflammation and restores BDNF in MPTP model of Parkinson’s disease in rats Baninder Kaur, Atish Prakash

Volume 22, Issue 1, Pages (March 2015)

Ontogeny of pulmonary cyclooxygenase-1 (COX-1) and -2 (COX-2)

Tetrandrine prevents monocrotaline-induced pulmonary arterial hypertension in rats through regulation of the protein expression of inducible nitric oxide.

Pentoxifylline protects against loss of function and renal interstitial fibrosis in chronic experimental partial ureteral obstruction Hongbao Ma, Steven.

Folic acid protects against experimental prenatal nicotine–induced cardiac injury by decreasing inflammatory changes, serum TNF and COX-2 expression

Limb compression induces multi-system genetic damage in rats

Junad Khan, Noma Noboru, Andrew Young, Davis Thomas Pathophysiology

Volume 18, Issue 3, Pages (June 2011)

Volume 20, Issue 2, Pages (April 2013)

Volume 24, Issue 4, Pages (December 2017)

Comparative study of the effect of verapamil and vitamin D on iron overload-induced oxidative stress and cardiac structural changes in adult male rats

Role of vitamin C and selenium in attenuation of nicotine induced oxidative stress, P53 and Bcl2 expression in adult rat spleen Marwa A. Ahmed, K.H.

Calcitonin and Omega–3 Fatty Acids Exhibit Antagonistic and Non-Additive Effects in Experimental Diabetes Wale Johnson Adeyemi, Luqman Aribidesi Olayaki

Resveratrol increases serum adiponectin level and decreases leptin and insulin level in an experimental model of hypercholesterolemia A. Jimoh, Y. Tanko,

Volume 23, Issue 4, Pages (December 2016)

Volume 22, Issue 4, Pages (December 2015)

Volume 81, Issue 12, Pages (June 2012)

The pathophysiology of abdominal aortic aneurysm growth: Corresponding and discordant inflammatory and proteolytic processes in abdominal aortic and popliteal.

Effect of short term treatment of L-carnitine on tissue ACE activity in streptozotocin- induced diabetic rats Ali M. Sharifi, Behnoush Zare, Morteza Keshavarz,

Vitamin D reduces high-fat diet induced weight gain and C-reactive protein, increases interleukin-10, and reduces CD86 and caspase-3 Asmaa M.S. Gomaa,

Volume 25, Issue 4, Pages (December 2018)

Folic acid protects against lead acetate-induced hepatotoxicity by decreasing NF-κB, IL- 1β production and lipid peroxidation mediataed cell injury Eman.

Volume 15, Issue 1, Pages 1-8 (June 2008)

Volume 26, Issue 1, Pages (March 2019)

L-Arginine supplementation enhances antioxidant activity and erythrocyte integrity in sickle cell anaemia subjects M.O. Kehinde, S.I. Ogungbemi, C.N.

Volume 18, Issue 4, Pages (September 2011)

Volume 21, Issue 2, Pages (June 2014)

Rats exposed to 2.45GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3 Rini Varghese, Anuradha.

Volume 25, Issue 2, Pages (June 2018)

Interleukin-6 participation in pathology of ocular diseases

Dietary macronutrients modulate hypertrophy and contractility of the detrusor in an experimental model of bladder obstruction Temitope G. Adedeji, Adesoji.

Peripheral brain-derived neurotrophic factor is reduced in stroke survivors with cognitive impairment Tasneem M. Hassan, Isyaku U. Yarube Pathophysiology

Volume 16, Issue 1, Pages (June 2009)

Experimental maternal treatment with dexamethasone during lactation induces neonatal testicular and epididymal oxidative stress; Implications for early.

Volume 62, Issue 3, Pages (September 2002)

Angiotensin converting enzyme inhibitor captopril modifies conditioned place preference induced by morphine and morphine withdrawal signs in rats Hojjatallah.

Increasing incidence of brain tumours in sparsely populated areas

M.-J. Wu, M.-C. Wen, Y.-T. Chiu, Y.-Y. Chiou, K.-H. Shu, M.-J. Tang

Ret mouse very large tumors (VLTs) display altered ratios of infiltrating memory to naive T cells: Roles in tumor expansion Mohammad W. Khan, Viktor.

The impact of psychogenic stressors on oxidative stress markers and patterns of CYP2E1 expression in mice liver Oksana Maksymchuk, Mykola Chashchyn

Pulmonary overexpression of inhibitor κBα decreases the severity of ventilator-induced lung injury in a rat model M. Hayes, G.F. Curley, C. Masterson,

Volume 26, Issue 2, Pages (June 2019)

Matrix metalloproteinase inhibitor regulates inflammatory cell migration by reducing ICAM-1 and VCAM-1 expression in a murine model of toluene diisocyanate-induced.

Presentation transcript:

Volume 24, Issue 2, Pages 81-89 (June 2017) Lung injury induced by Bisphenol A: A food contaminant, is ameliorated by selenium supplementation Azza S. Abedelhaffez, Ebtihal A. Abd El-Aziz, Mohamed A. Abdel Aziz, Asmaa M. Ahmed Pathophysiology Volume 24, Issue 2, Pages 81-89 (June 2017) DOI: 10.1016/j.pathophys.2017.02.003 Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 1 (A& B) Mean lung homogenate levels of MDA and SOD of the studied groups. Data are displayed as mean±SEM of eight rats. *P<0.05 as compared to control group. # P<0.05 as compared to BPA group. Pathophysiology 2017 24, 81-89DOI: (10.1016/j.pathophys.2017.02.003) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 2 Representative RT-PCR detection of IL-18 mRNA fragments in lung tissue homogenates of the studied groups. β-actin was used in parallel as an internal control. Pathophysiology 2017 24, 81-89DOI: (10.1016/j.pathophys.2017.02.003) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 3 Representative Western blotting analysis of FSTL1 in lung tissue homogenates of the studied groups. β-actin was used in parallel as an internal control. Pathophysiology 2017 24, 81-89DOI: (10.1016/j.pathophys.2017.02.003) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 4 Representative Western blotting analysis of ADAMTS5 in lung tissue homogenates of the studied groups. β-actin was used in parallel as an internal control. Pathophysiology 2017 24, 81-89DOI: (10.1016/j.pathophys.2017.02.003) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 5 Histopathological changes in lung tissue from rats of the studied groups: A),B) control and Se groups revealed normal alveoli and interstitial tissue. C) BPA group revealed thickening of the alveolar walls by heavy chronic inflammatory cellular infiltrate (lymphocytes) and fibrosis. D) BPA+ Se group revealed significant decrease of the lung damage with reduction in the chronic inflammatory cellular infiltrate and fibrosis. Pathophysiology 2017 24, 81-89DOI: (10.1016/j.pathophys.2017.02.003) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 6 Immunohistochemical expression of FSTL1 & ADAMTS5 of the studied groups (400x): A) & B) Weak FSTL1 expression in control and Se groups. C) Strong FSTL1 cytoplasmic expression in alveolar epithelium and fibrotic areas in alveolar wall of BPA group. D) Moderate FSTL1 cytoplasmic expression in alveolar epithelium of BPA +Se group. E) & F) Moderate ADAMTS5 expression in bronchial smooth muscle of control and Se groups. G) Weak ADAMTS5 expression in bronchial smooth muscle of BPA group. H) Strong ADAMTS5 expression in bronchial smooth muscle of BPA +Se group. I) & J) Moderate ADAMTS5 cytoplasmic expression in alveolar epithelium of control and Se groups. K) Weak ADAMTS5 cytoplasmic expression in alveolar epithelium of BPA group. L) Strong ADAMTS5 cytoplasmic expression in alveolar epithelium of BPA +Se group. Pathophysiology 2017 24, 81-89DOI: (10.1016/j.pathophys.2017.02.003) Copyright © 2017 Elsevier B.V. Terms and Conditions

Fig. 7 (A &B) Mean FSTL1 and ADAMTS5 expressions of the studied groups. Data are displayed as mean±SEM of eight rats. *P<0.05 as compared to control group. # P<0.05 as compared to BPA group. Pathophysiology 2017 24, 81-89DOI: (10.1016/j.pathophys.2017.02.003) Copyright © 2017 Elsevier B.V. Terms and Conditions