N. J. Verkaik, A. Lebon, C. P. de Vogel, H. Hooijkaas, H. A

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Induction of antibodies by Staphylococcus aureus nasal colonization in young children N.J. Verkaik, A. Lebon, C.P. de Vogel, H. Hooijkaas, H.A. Verbrugh, V.W.V. Jaddoe, A. Hofman, H.A. Moll, A. van Belkum, W.J.B. van Wamel Clinical Microbiology and Infection Volume 16, Issue 8, Pages 1312-1317 (August 2010) DOI: 10.1111/j.1469-0691.2009.03073.x Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Levels of IgG, IgA and IgM directed against toxic shock syndrome toxin-1 (TSST-1), clumping factor B (ClfB) and extracellular fibrinogen-binding protein (Efb) in 57 children at birth, 6 months, 14 months and 24 months. Antibody levels are reflected by median fluorescence intensity values. Each dot represents a serum sample. Median values are indicated by horizontal lines. Clinical Microbiology and Infection 2010 16, 1312-1317DOI: (10.1111/j.1469-0691.2009.03073.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 (a) Relationship between Staphylococccus aureus colonization in the first year of life and levels of antistaphylococcal IgG, reflected by median fluorescence intensity (MFI) values, at 14 months. Each symbol represents a single child. Red triangles represent colonized children, and blue diamonds represent non-colonized children. Median values are indicated by horizontal lines. (b) Relationship between S. aureus colonization in the first 2 years of life and the level of IgG at 24 months. CHIPS, chemotaxis inhibitory protein of S. aureus; SCIN, staphylococcal complement inhibitor; Efb, extracellular fibrinogen-binding protein; Clf, clumping factor; Sdr, serine-aspartate dipeptide repeat protein; Fnbp, fibronectin-binding protein; Isd, iron-responsive surface determinant; SasG, S. aureus surface protein G; SE, staphylococcal enterotoxin; TSST-1, toxic shock syndrome toxin-1. Clinical Microbiology and Infection 2010 16, 1312-1317DOI: (10.1111/j.1469-0691.2009.03073.x) Copyright © 2010 European Society of Clinical Infectious Diseases Terms and Conditions