TRF2ΔBΔM induces apoptosis and senescence in the mouse liver.

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Date of download: 10/22/2017 Copyright © ASME. All rights reserved.

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TRF2ΔBΔM induces apoptosis and senescence in the mouse liver. TRF2ΔBΔM induces apoptosis and senescence in the mouse liver. Apoptosis was determined by TUNEL assay on liver sections from mice infected with Ad TRF2ΔBΔM or Ad GFP (1 × 1010 PFU/ml, n=21 mice per group, n=3 mice per time point). (A) Percentage of apoptotic liver cells at the indicated time points. Note that Ad TRF2ΔBΔM induced significantly higher rates of apoptosis compared with Ad GFP‐infected mice at early time points when maximal levels of TRF2ΔBΔM were expressed (P=0.01 at day 2 after virus infection; P=0.05 at day 3 after virus infection). (B) Representative photographs of apoptotic liver cells as detected by TUNEL assay at the indicated time points after virus infection (magnification: × 200). (C) Representative photographs of SA‐β‐Gal‐positive liver cells 48 h after Ad TRF2ΔBΔM (top) and Ad GFP infection (bottom) (magnification: × 200). (D) Percentage of liver cells positive for SA‐β‐Gal staining in Ad TRF2ΔBΔM‐infected mice compared with Ad GFP‐infected mice. André Lechel et al. EMBO Rep. 2005;6:275-281 © as stated in the article, figure or figure legend