Alternative Splicing of CD45: The Tip of the Iceberg

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Presentation transcript:

Alternative Splicing of CD45: The Tip of the Iceberg Julie Zikherman, Arthur Weiss Immunity Volume 29, Issue 6, Pages 839-841 (December 2008) DOI: 10.1016/j.immuni.2008.12.005 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Alternative Splicing of CD45 Alternative splicing of exons 4, 5, and 6 in naive T cells permits the inclusion of heavily glycosylated segments A, B, and C, respectively, in CD45 cell-surface protein. Variable amounts of high molecular weight isoforms, including RABC, RAB, RBC, and RB are detected on the surface of naive T cells. Upon differentiation to memory T cells, upregulation of hnRNPLL inhibits splicing and inclusion of exons 4, 5, and 6, generating predominantly the short isoform CD45RO. Immunity 2008 29, 839-841DOI: (10.1016/j.immuni.2008.12.005) Copyright © 2008 Elsevier Inc. Terms and Conditions