Protein Networks in Alzheimer’s Disease

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Protein Networks in Alzheimer’s Disease Eva Meier Carlsen, Rune Rasmussen Cell Systems Volume 4, Issue 2, Pages 153-155 (February 2017) DOI: 10.1016/j.cels.2017.02.006 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 A Potential Role of Glia Cells and the Development of Symptomatic Alzheimer’s Disease As Alzheimer’s disease develop and progress through the asymptotic state to clinical Alzheimer’s disease, the level of neuronal synaptic proteins decreases. (Top) Using quantitative proteomics, Seyfried et al. found that glia cell protein markers are similar in brain tissue samples from healthy and in asymptotic Alzheimer’s disease individuals, but are found in greater abundance in samples from individuals in the clinical Alzheimer’s disease phase. (Bottom) This suggests that the increase in glia cell protein networks may tip the scale and lead to synaptic and memory loss in symptomatic Alzheimer’s disease patients. Cell Systems 2017 4, 153-155DOI: (10.1016/j.cels.2017.02.006) Copyright © 2017 Elsevier Inc. Terms and Conditions