Ian Macara, Alicia Smith

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Ian Macara, Alicia Smith Ran Ian Macara, Alicia Smith Current Biology Volume 10, Issue 15, (August 2000) DOI: 10.1016/S0960-9822(00)00605-9

Figure. Ran and nuclear transport. Importins (I; green) bind their cargo (C; yellow) in the cytoplasm. Ran–GTP (green hexagons) binds importin in the nucleus and releases the cargo. Exportins (E; orange) bind their cargo (C; pink) and Ran–GTP in the nucleus. Hydrolysis of GTP in the cytoplasm to Ran–GDP (grey hexagons) releases the cargo. Ran–GDP is recycled back into the nucleus by NTF2 (N; blue). Current Biology 2000 10, DOI: (10.1016/S0960-9822(00)00605-9)