Volume 366, Issue 9503, Pages 2087-2106 (December 2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials The Lancet Volume 366, Issue 9503, Pages 2087-2106 (December 2005) DOI: 10.1016/S0140-6736(05)67887-7 Copyright © 2005 Elsevier Ltd Terms and Conditions
Figure 1 Effect of radiotherapy (RT) after BCS (ten trials) on local recurrence and on breast cancer mortality—event rate ratios O–E=observed–expected. BW=breast/chest wall. S=scar (as site of RT boost). AF=axilla/fossa. IMC=internal mammary chain. Sites in parentheses not always treated. *Some systemic adjuvant therapy (same polychemotherapy and/or tamoxifen) in both groups. 99% CIs are given for trial-specific results (black squares) and 95% CIs are given for subtotals and totals (white diamonds). The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions
Figure 2 Effect of radiotherapy (RT) after BCS on local recurrence and on breast cancer mortality—15-year probabilities Data from 10 trials. Vertical lines indicate 1 SE above or below the 5, 10, and 15 year percentages. The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions
Figure 3 Effect of radiotherapy (RT) after mastectomy and axillary clearance (AC) on local recurrence and on breast cancer mortality—15-year probabilities Data from 25 trials. Vertical lines indicate 1 SE above or below the 5, 10, and 15 year percentages. The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions
Figure 4 Absolute reduction in 5-year local recurrence risk—78 randomised comparisons grouped into 24 types of local treatment comparison, based on treatments compared and nodal status RT=radiotherapy. AC=axillary clearance. AS=axillary sampling. IMC=internal mammary chain of lymph nodes. *A few trials did not provide data on local recurrence, so in some comparisons numbers differ from table 1. The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions
Figure 5 Local recurrence and breast cancer mortality for treatment comparisons that produce a less than 10% (upper panels) or more than 10% (lower panels) absolute reduction in 5-year local recurrence risk—15-year probabilities Vertical lines indicate 1 SE above or below the 5, 10, and 15 year percentages. The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions
Figure 6 Effect of radiotherapy (RT) on breast cancer mortality and on all-cause mortality after BCS or after mastectomy with axillary clearance (AC)—15-year or 20-year probabilities Vertical lines indicate 1 SE above or below the 5, 10, and 15 year percentages. The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions