Volume 366, Issue 9503, Pages (December 2005)

Slides:



Advertisements
Similar presentations
Evidence Based For invasive breast cancer BCT is Tumor excision, axillary node dissection, whole breast radiation Modified mastectomy is total mastectomy.
Advertisements

How surgeons can find information online? Martin Hewitt International Journal of Surgery Volume 5, Issue 6, Pages (December 2007) DOI: /j.ijsu
Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials The Lancet Volume 386, Issue.
Aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta- analysis of the randomised trials The Lancet Volume 386, Issue 10001,
Volume 376, Issue 9753, Pages (November 2010)
Volume 355, Issue 9212, Pages (April 2000)
Volume 8, Issue 12, Pages (December 2007)
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials  Cholesterol.
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised.
Volume 373, Issue 9660, Pages (January 2009)
Bipolar treatment efficacy
Volume 376, Issue 9734, Pages (July 2010)
Volume 373, Issue 9679, Pages (June 2009)
Thank God for Richard Dawkins?
Long-term effects of hormone replacement therapy
The benefits and harms of breast cancer screening
Patricia A. Ganz, MD  The American Journal of Medicine 
Intellectual property of the EBCTCG trialists.
Volume 378, Issue 9804, Pages (November 2011)
Meta-analysis of randomised controlled trials
Volume 5, Issue 4, Pages (April 2006)
Intraoperative radiotherapy for early breast cancer
Low-level laser therapy for neck pain
Volume 376, Issue 9734, Pages (July 2010)
Volume 9, Issue 12, Pages (December 2008)
Volume 13, Issue 3, Pages (March 2012)
Long-term effects of hormone replacement therapy
Aspirin in the prevention of cancer – Author's reply
Volume 374, Issue 9707, Pages (December 2009)
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials  Cholesterol.
Volume 373, Issue 9679, Pages (June 2009)
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised.
Volume 366, Issue 9484, Pages (August 2005)
Volume 375, Issue 9722, Pages (April 2010)
Adjuvant chemotherapy for rectal cancer – Authors' reply
Patricia A. Ganz, MD  The American Journal of Medicine 
Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies  Prospective Studies Collaboration  The.
Ovarian cancer screening: UKCTOCS trial – Authors' reply
Volume 383, Issue 9935, Pages (June 2014)
Meta-analysis of randomised controlled trials
Volume 386, Issue 10001, Pages (October 2015)
Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100 000 women in 123 randomised.
Psychological response and survival in breast cancer
Mark K Ferguson, MD, Amy G Lehman, BA  The Annals of Thoracic Surgery 
Volume 386, Issue 10001, Pages (October 2015)
Volume 373, Issue 9660, Pages (January 2009)
Infant-feeding patterns and HIV-1 transmission
Volume 376, Issue 9753, Pages (November 2010)
Volume 371, Issue 9627, Pages (May 2008)
Volume 376, Issue 9757, Pages (December 2010)
Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials  Cholesterol.
Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials 
Volume 9, Issue 4, Pages (April 2008)
Volume 382, Issue 9894, Pages (August 2013)
Thank God for Richard Dawkins?
Volume 373, Issue 9658, Pages (January 2009)
Department of Error The Lancet Volume 369, Issue 9564, (March 2007)
Volume 373, Issue 9658, Pages (January 2009)
Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient.
Volume 11, Issue 3, Pages (March 2010)
Volume 373, Issue 9672, Pages (April 2009)
Volume 371, Issue 9618, Pages (March 2008)
Arlene Chan, Marc Buyse, Bin Yao  The Lancet Oncology 
Steven A Narod  The Lancet  Volume 349, Issue 9068, (June 1997)
Impact of renal function on the effects of LDL cholesterol lowering with statin-based regimens: a meta-analysis of individual participant data from 28.
Genetic enhancement of radionuclide cancer therapy
Effects on 11-year mortality and morbidity of lowering LDL cholesterol with simvastatin for about 5 years in 20 536 high-risk individuals: a randomised.
Cholesterol and all-cause mortality in Honolulu
THE LANCET Oncology Volume 19, No. 1, p27–39, January 2018
Clinic attendance and disengagement of young adults with type 1 diabetes after transition of care from paediatric to adult services (TrACeD): a randomised,
Presentation transcript:

Volume 366, Issue 9503, Pages 2087-2106 (December 2005) Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials    The Lancet  Volume 366, Issue 9503, Pages 2087-2106 (December 2005) DOI: 10.1016/S0140-6736(05)67887-7 Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 1 Effect of radiotherapy (RT) after BCS (ten trials) on local recurrence and on breast cancer mortality—event rate ratios O–E=observed–expected. BW=breast/chest wall. S=scar (as site of RT boost). AF=axilla/fossa. IMC=internal mammary chain. Sites in parentheses not always treated. *Some systemic adjuvant therapy (same polychemotherapy and/or tamoxifen) in both groups. 99% CIs are given for trial-specific results (black squares) and 95% CIs are given for subtotals and totals (white diamonds). The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 2 Effect of radiotherapy (RT) after BCS on local recurrence and on breast cancer mortality—15-year probabilities Data from 10 trials. Vertical lines indicate 1 SE above or below the 5, 10, and 15 year percentages. The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 3 Effect of radiotherapy (RT) after mastectomy and axillary clearance (AC) on local recurrence and on breast cancer mortality—15-year probabilities Data from 25 trials. Vertical lines indicate 1 SE above or below the 5, 10, and 15 year percentages. The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 4 Absolute reduction in 5-year local recurrence risk—78 randomised comparisons grouped into 24 types of local treatment comparison, based on treatments compared and nodal status RT=radiotherapy. AC=axillary clearance. AS=axillary sampling. IMC=internal mammary chain of lymph nodes. *A few trials did not provide data on local recurrence, so in some comparisons numbers differ from table 1. The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 5 Local recurrence and breast cancer mortality for treatment comparisons that produce a less than 10% (upper panels) or more than 10% (lower panels) absolute reduction in 5-year local recurrence risk—15-year probabilities Vertical lines indicate 1 SE above or below the 5, 10, and 15 year percentages. The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions

Figure 6 Effect of radiotherapy (RT) on breast cancer mortality and on all-cause mortality after BCS or after mastectomy with axillary clearance (AC)—15-year or 20-year probabilities Vertical lines indicate 1 SE above or below the 5, 10, and 15 year percentages. The Lancet 2005 366, 2087-2106DOI: (10.1016/S0140-6736(05)67887-7) Copyright © 2005 Elsevier Ltd Terms and Conditions