Ketamine* Journal of Pain and Symptom Management

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Presentation transcript:

Ketamine* Journal of Pain and Symptom Management Rachel Quibell, FRCP, Marie Fallon, MD, FRCP, Mary Mihalyo, BS, PharmD, BCPS, Robert Twycross, DM, FRCP, Andrew Wilcock, DM, FRCP Journal of Pain and Symptom Management Volume 50, Issue 2, Pages 268-278 (August 2015) DOI: 10.1016/j.jpainsymman.2015.06.002 Copyright © 2015 Terms and Conditions

Fig. 1 Diagram of the NMDA (excitatory) receptor-channel complex. The channel is blocked by magnesium (Mg2+) when the membrane potential is at its resting level (voltage-dependent block) and by drugs which act at the phencyclidine (PCP) binding site in the glutamate-activated channel, e.g. dextromethorphan, ketamine, methadone (use-dependent block).4 Journal of Pain and Symptom Management 2015 50, 268-278DOI: (10.1016/j.jpainsymman.2015.06.002) Copyright © 2015 Terms and Conditions