Making Ends Meet: Myeloid Cells Catalyze Blood Vessel Repair in the Brain Aleksandra Deczkowska, Michal Schwartz Immunity Volume 44, Issue 5, Pages 1081-1083 (May 2016) DOI: 10.1016/j.immuni.2016.04.024 Copyright © 2016 Elsevier Inc. Terms and Conditions
Figure 1 Myeloid Cells’ Roles in Acute CNS Injury Upon rupture of a blood vessel in the brain, the tissue immediately shows signs of stress, e.g., microglia activation and neuronal death. Under these conditions, myeloid cells (both microglia and infiltrating, monocyte-derived macrophages) fulfill a range of protective roles, including phagocytosis of cellular debris, release of neuroprotective factors, and, as now reported by Liu et al. (2016), directly supporting re-ligation of ruptured blood vessels by adhesion and mechanical traction. Immunity 2016 44, 1081-1083DOI: (10.1016/j.immuni.2016.04.024) Copyright © 2016 Elsevier Inc. Terms and Conditions