Hereditary Nonpolyposis Colorectal Cancer in 95 Families: Differences and Similarities between Mutation-Positive and Mutation-Negative Kindreds Rodney.

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Hereditary Nonpolyposis Colorectal Cancer in 95 Families: Differences and Similarities between Mutation-Positive and Mutation-Negative Kindreds Rodney J. Scott, Mary McPhillips, Cliff J. Meldrum, Patrick E. Fitzgerald, Kirsten Adams, Allan D. Spigelman, Desiree du Sart, Kathy Tucker, Judy Kirk The American Journal of Human Genetics Volume 68, Issue 1, Pages 118-127 (January 2001) DOI: 10.1086/316942 Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 1 Complex DNA sequence changes identified in hMSH2 The American Journal of Human Genetics 2001 68, 118-127DOI: (10.1086/316942) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 2 Age at diagnosis in 292 patients with familial colorectal carcinoma, according to mutation status. One to six affected mutation-positive family members were included in this analysis, and only hMSH2 and hMLH1 causative mutations were included. The American Journal of Human Genetics 2001 68, 118-127DOI: (10.1086/316942) Copyright © 2001 The American Society of Human Genetics Terms and Conditions

Figure 3 Relative percentage of malignancies within the three groups of families with HNPCC. The tumor spectrum was determined on the basis of 559 patients with cancer, all of whom were from families with a clustering of CRC. The American Journal of Human Genetics 2001 68, 118-127DOI: (10.1086/316942) Copyright © 2001 The American Society of Human Genetics Terms and Conditions