Linkage Analysis Using Co-Phenotypes in the BRIGHT Study Reveals Novel Potential Susceptibility Loci for Hypertension Chris Wallace, Ming-Zhan Xue, Stephen.

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Linkage Analysis Using Co-Phenotypes in the BRIGHT Study Reveals Novel Potential Susceptibility Loci for Hypertension Chris Wallace, Ming-Zhan Xue, Stephen J. Newhouse, Ana Carolina B. Marçano, Abiodun K. Onipinla, Beverley Burke, Johannie Gungadoo, Richard J. Dobson, Morris Brown, John M. Connell, Anna Dominiczak, G. Mark Lathrop, John Webster, Martin Farrall, Charles Mein, Nilesh J. Samani, Mark J. Caulfield, David G. Clayton, Patricia B. Munroe The American Journal of Human Genetics Volume 79, Issue 2, Pages 323-331 (August 2006) DOI: 10.1086/506370 Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 1 P values for body mass and renal function–related traits that achieved genomewide significance on chromosomes 20 and 5, respectively. The results of the analysis of raw residuals and ranked data are shown in the top and bottom panels, respectively. The dotted line indicates the genomewide 5% significance threshold. The American Journal of Human Genetics 2006 79, 323-331DOI: (10.1086/506370) Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 2 Genomewide score statistics for analysis of all ranked covariates studied. The score statistic is shown on the vertical scale. The upper and lower horizontal dashed lines represent the adjusted and unadjusted, respectively, thresholds for genomewide significance for the multiple covariates. GGT = γ-glutamyl transpeptidase; SBP = systolic blood pressure; DBP = diastolic blood pressure. The American Journal of Human Genetics 2006 79, 323-331DOI: (10.1086/506370) Copyright © 2006 The American Society of Human Genetics Terms and Conditions