Basal Ganglia Lec 13.

Slides:

Advertisements

Similar presentations

Cortically OriginatedMovement Cortically Originated Movement I. Motor Tract (corticospinal tractus) Extrapyramidal System (basal ganglia) Cerebellum Praxis.

Advertisements

Parkinson's Disease Animal Models and Possible Treatments.

Motor Control and Disorders. Basal Ganglia Disorders Parkinson’s Disease Huntington’s Disease Tourette’s Syndrome.

By Lisa Rosenberg Deep Brain Stimulation. Electrical probe implanted in brain Approved by FDA in mid 1990’s Hidden under skin Does not damage healthy.

Approach to diagnosis and treatment of dystonia Terence D. Sanger University of Southern California Dept. Biomedical Engineering, Child Neurology, Biokinesiology.

Movement part 2. Cerebellum and Brainstem KW p. 363.

Brain Control of Movement. Motor Control Hierarchy  High level – plans and executes strategy Association areas of cortex Basal ganglia gives the “go”

Huntington’s Disease I: Symptoms and Circuits Neurobiology of Disease.

Neural Control of Muscle. Quick Review: Spinal Cord Flexors Extensors.

A preliminary model for the role of the basal ganglia in natural motor control and motor programming MURI Meeting, June 4th, 2002 Steve Massaquoi, Zhi-Hong.

Brain pacemakers – developing closed loop stimulation Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London,

Electrical stimulation of the brain: Deep Brain Stimulation (DBS)

Is it a neurodegenerative brain disorder that progresses slowly in most people.

Deep Brain Stimulation For parkinson’s disease

NEUROLOGICAL DISORDERS. Dementia  A degenerative syndrome characterized by deficits in memory, language, and mood.  The most common form: Alzheimer’s.

Movement Disorders General Overview. BASAL GANGLIA CIRCUITRY.

Parkinson’s Disease By Devin Cornford

Deep Brain Stimulation: Brain Pacemakers Kaitlin Abbate.

Neurological Manifestations of Wilson’s Disease Aleksandar Videnovic, MD, MSc Assistant Professor of Neurology Feinberg School of Medicine Northwestern.

Duodenal Levodopa Treatment in advanced Parkinson’s Disease

Aaron Mulheren, Kathryn Wilson, MSN, APN, Milind Deogaonkar, MD

Making Things Happen - 2 Motor Disorders How Your Brain Works - Week 7 Dr. Jan Schnupp HowYourBrainWorks.net.

MODELING THE PARKINSONIAN TREMOR AND ITS TREATMENT Supervisor : Dr Towhidkhah Designed by Yashar Sarbaz Amirkabir University of Technology.

Neuroscience 1 Pause for thought: Probably 100 million neurones fire during skilled movements.

The Effects of Deep Brain Stimulation on the Motor Symptoms of Parkinson’s Disease Aaron Mulheren Kathryn Wilson, MSN, APN Milind Deogaonkar, MD Science.

Surgery for Parkinson’s Disease: Focus on Deep Brain Stimulation Ramón L Rodríguez, MD Director of Clinical Services University of Florida Movement Disorders.

BY: MACKENZIE SOARES ALYSSA MEDIEROS STEPHANIE GARDNER Parkinson's Disease.

PARKINSON’S DISEASE By Courtney and Niral. WHAT IS IT?  Parkinson's disease (PD) is chronic and progressive movement disorder, meaning that symptoms.

PhD MD MBBS Faculty of Medicine Al Maarefa Colleges of Science & Technology Faculty of Medicine Al Maarefa Colleges of Science & Technology Lecture – 9:

Teaching NeuroImages An 83-year-old woman with phonatory breaks and left hand rest tremor Neurology Resident and Fellow Section © 2013 American Academy.

Mostly Parkinson’s disease but also few other movement disorders due to diseases of the basal ganglia.

BRAIN PACEMAKERS Madison Moreau BME 281 September 26, 2012.

Temporal Enhancement of Motor Control in Parkinson’s Disease patients Marta Bieńkiewicz PhD Student Queen’s University Belfast.

Quantitative Detection of Parkinson's Disease Symptoms Advisor: Dr. Chris Kao Project Team: Kylen Bares Eddie Cao.

A Pacemaker For Your Brain

NEUROLOGICAL DISORDERS. Dementia  A degenerative syndrome characterized by deficits in memory, language, and mood.  The most common form: Alzheimer’s.

 Parkinson’s Disease (PD) -progressive neurodegenerative disease affecting motor ability -third most common neurologic disorder of older adults.

NERVOUS SYSTEM Sydney Hirrschoff. NERVOUS SYSTEM FUNCTION The nervous system is made up of the brain, spinal cord, sensory organs, and all of the nerves.

Quantitative Detection of Parkinson's Disease Symptoms Advisor: Dr. Anita Mahadevan-Jansen Faraz Ali James Lugge Ernest Moore Mahesh Parlikad.

Quantitative Detection of Parkinson's Disease Symptoms Advisor: Dr. Chris Kao Project Team: Kylen Bares Eddie Cao.

Quantitative Detection of Parkinson's Disease Symptoms Advisor: Dr. Anita Mahadevan-Jansen Faraz Ali James Lugge Ernest Moore Mahesh Parlikad.

Neurological Disorders

Figure 18.1 Motor components of the human basal ganglia.

Not a response to reward itself, but to information about reward More than predicted in ‘previous state’ = increased activity; positive prediction.

The organization of the nervous system. Structure of the human cerebral cortex.

Α-synuclein transgenic mouse models of Parkinson’s disease Michelle Maurer December 2015.

Parkinson's disease By Colby Allen. symptoms Mild to major tremors. Rigidity or joint stiffness Bradykinesia or slowness of movement Postural instability.

Parkinson’s Test Device Development Tiffany Feltman Erin Sikkel.

STRUCTURE AND CIRCUITS OF THE BASAL GANGLIA Rastislav Druga Inst. of Anatomy, 2nd Medical Faculty.

Basal Ganglia—Their Motor Functions 1- Receives from brain and back to it again 2- Function of the Basal Ganglia— The Putamen Circuit: 3- Abnormal Function.

Deep Brain Stimulation Surgery in India. Deep Brain Stimulation can help to treat with many symptoms caused by the following movement disorders: Parkinson’s.

How is Parkinson’s disease Diagnosed? And What Are the Treatment options?

Quantitative Detection of Parkinson's Disease Symptoms Advisor: Dr. Anita Mahadevan-Jansen Faraz Ali James Lugge Ernest Moore Mahesh Parlikad.

MOVEMENT DISORDERS.

Parkinson's disease KRZYSZTOF NICPOŃ.

Organization of Neural Structures Involved in the Control of Movement

Prediction of Parkinson’s Disease Tremor Onset Using Artificial Neural Networks Kevin Warwick.

“The effects of chronic changes to the functioning of the nervous system due to interference to neurotransmitter function, illustrated by the role of Dopamine.

Parkinson’s disease.

Parkinson's disease Parkinson's disease (PD) is the second-most common

Andres M. Lozano, Nir Lipsman Neuron

Quantitative Detection of Parkinson's Disease Symptoms

Atypical Parkinsonian Syndromes

Organization of Neural Structures Involved in the Control of Movement

Quantitative Detection of Parkinson's Disease Symptoms

MODELING THE PARKINSONIAN TREMOR AND ITS TREATMENT

Basal ganglia It is a collection of grey matter deeply in each

Stimulation on Demand: Closing the Loop on Deep Brain Stimulation

Deep Brain Stimulation: What, When, Why, How

HOW DOES EXPERIENCE AFFECT BEHAVIOUR AND MENTAL PROCESSES?

Presentation transcript:

Basal Ganglia Lec 13

Major Diseases of the Basal Ganglia Parkinson’s disease Huntington’s disease Hemiballism Athetosis Dystonia Restless Leg Syndrome Psychiatric diseases (OCD), Tourette’s syndrome

IT IS :Parkinson’s Disease

Motor Symptoms:- The Cardinal signs of PD are :- 1- Tremor (Resting tremor). 2- Rigidity (muscle stiffness) 3- Brady Kinesia/ Akinesia. 4- Postural instability.

Dauer W, Przedborski S. Parkinson's disease: mechanisms and models Dauer W, Przedborski S.. Parkinson's disease: mechanisms and models. Neuron. 2003 39:889-909.

Schapira AH, Olanow CW.. Neuroprotection in Parkinson disease: mysteries, myths, and misconceptions. JAMA. 2004 Jan 21;291(3):358-64.

Deep Brain Stimulation (DBS) DBS targets areas in the brain where uncontrolled movements originate. The targeted region is inactivated, not destroyed, by an implanted electrode. The electrode is connected via a wire running beneath the skin to a stimulator and battery pack in the patient's chest.

Deep Brain Stimulation (DBS)