A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion.

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Presentation transcript:

A novel peroxynitrite decomposer catalyst (FP-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion in pigs Cesario Bianchi, MD, PhD, Hidetaka Wakiyama, MD, Renato Faro, PhD, Tanveer Khan, MD, James D McCully, PhD, Sidney Levitsky, MD, Csaba Szabó, MD, Frank W Sellke, MD The Annals of Thoracic Surgery Volume 74, Issue 4, Pages 1201-1207 (October 2002) DOI: 10.1016/S0003-4975(02)03953-X

Fig 1 Evolution of positive first derivative of left ventricular pressure over time (+dP/dt) in control (n = 6) and FP-15-treated animals (n = 6) throughout the experiment. *p< 0.05. (–○– = control; –■– = FP-15.) The Annals of Thoracic Surgery 2002 74, 1201-1207DOI: (10.1016/S0003-4975(02)03953-X)

Fig 2 Evolution of coronary blood flow in control (n = 6) and FP-15 (n = 6)-treated pigs. Coronary blood flow was continuously monitored using a transit time ultrasonic flow probe (3-mm RS-Series) placed around the left anterior descending coronary artery connected to a T206 flowmeter. *p< 0.01. (–○– = control; –■– = FP-15.) The Annals of Thoracic Surgery 2002 74, 1201-1207DOI: (10.1016/S0003-4975(02)03953-X)

Fig 3 Histograms showing the area at risk (left) and infarct size (right) in the left ventricle (LV) at the end of the experimental protocol in control (n = 6) and FP-15-treated pigs (n = 6). Values are expressed as mean ± standard error of the mean. *p< 0.05. The Annals of Thoracic Surgery 2002 74, 1201-1207DOI: (10.1016/S0003-4975(02)03953-X)

Fig 4 Evolution of segment shortening in the ischemic area (n = 6) of control and FP-15 (n = 6)-treated pigs. Regional myocardial function was obtained by sonomicrometry using piezoelectric ultrasonic probes (2.0 mm) implanted in the subendocardial layer. (–○– = control; –■– = FP-15.) The Annals of Thoracic Surgery 2002 74, 1201-1207DOI: (10.1016/S0003-4975(02)03953-X)

Fig 5 Immunohistochemical localization of nitrotyrosine in left ventricle sections from the ischemic area of (left) a control animal with unrelated isotype-matched first antibody (negative control); (middle) a control animal with anti-nitrotyrosine antibody; and (right) an FP-15-treated animal with anti-nitrotyrosine antibody. Left ventricular samples were harvested and frozen sections (10 μm) were processed for immunohistochemistry. Note the presence of nitrotyrosine (brown staining) in the tissue (middle) that is not present in the negative control (left) or in the myocardium of pigs treated with FP-15 (right). (MI/R= myocardial ischemia/reperfusion.) The Annals of Thoracic Surgery 2002 74, 1201-1207DOI: (10.1016/S0003-4975(02)03953-X)