Immune-mediated necrotising myopathy linked to statin use

Slides:

Advertisements

Similar presentations

Maintaining Cell Identity through Global Control of Genomic Organization Gioacchino Natoli Immunity Volume 33, Issue 1, Pages (July 2010) DOI: /j.immuni

Advertisements

Crohn's disease Prof Daniel C Baumgart, MD, Prof William J Sandborn, MD The Lancet Volume 380, Issue 9853, Pages (November 2012) DOI: /S (12)

Volume 4, Issue 2, Pages (February 2005)

Spontaneous aneurysm of the superficial temporal artery

Fatal consequences of an ear infection

Pharmacogenetics and future drug development and delivery

A cervical spine mass caused by Onchocerca lupi

Thank God for Richard Dawkins?

414. A Novel Clinical Severity Scoring Measure in Canine X-Linked Myotubular Myopathy: Results Following Systemic AAV Gene Replacement Molecular Therapy

Distinctly different purpura on different arms

The electronic future of scientific articles

Focal epithelial hyperplasia

Extremely large air distension of the bowel

Punishment beatings and the rule of law

Calciphylaxis The Lancet Volume 383, Issue 9922, (March 2014)

Abdominal lipohypertrophy without insulin injection

Gas in the retropharyngeal space: descending necrotising mediastinitis

A refractory rash in a seborrheic distribution

Dr Josè Vitale, MD, Prof Luigi Boni, MD, Nazario Brumana, MD

Striking cysts: recurrent haematuria in a kickboxer

Pycnodysostosis with a patella fracture

A twin with Cushing's disease

Disabling gout The Lancet Volume 376, Issue 9746, (September 2010)

Multiple chest wall swellings in adult Burkitt's lymphoma

Hurricane aorta The Lancet Volume 384, Issue 9960, (December 2014)

Gene therapy in haematology and oncology

Delayed presentation of acute aortic syndrome

Exploring the heart of the human heart

Gene therapy—where are we?

Mature teratoma arising from the sella

Non-uraemic calciphylaxis with acral necrosis

Dr María Asunción Pérez-Jacoiste Asín, MD, Gemma Ruiz Robles, RN

A cervical spine mass caused by Onchocerca lupi

Punishment beatings and the rule of law

Organisation of the care of patients with heart failure

Diabetic Muscle Infarction: Case Report of a Rare Complication

HIV myths should not be resuscitated

A Diagnostic Dilemma in a Patient with Polyarthritis

Pseudopseudohypoparathyroidism

DEPARTMENT OF ERROR The Lancet Volume 362, Issue 9385, (August 2003)

Striking cysts: recurrent haematuria in a kickboxer

Prosopometamorphopsia and facial hallucinations

Giant coronary aneurysm obstructing the right heart

Dysphagia in a young woman

Bilateral exudative retinal detachments in Sturge-Weber syndrome

The “alter ego” in psychiatry

Volume 362, Pages s6-s7 (December 2003)

Hemifacial sweating after carotid artery dissection

Tobias Breidthardt, MD, Dr Mehdi Namdar, MD, Prof Bernhard Hess, MD

Blue–black eyes and legs

What would happen if we stopped vaccination?

Spontaneous aneurysm of the superficial temporal artery

Confessions of a journal junkie

Telling it like it isn't: truth and lies in a post-9/11 world

Pituitary siderosis: the dark side of the pituitary

Dancing eyes and uvula after brain tumour extirpation—a sign of tumour progression? Dr Stefan Kipfer, MD, Christian Pirovino, MD, Marwan El-Koussy, MD,

Multiple endocrine carcinomas of the ileum

Treating excessive sweating with poison

Thank God for Richard Dawkins?

Low-technology approaches

Volume 378, Issue 9798, (October 2011)

Thank you to our diverse (but not diverse enough) reviewers

The passage of a colonic cast

Extramedullary haemopoiesis and spinal cord compression

Stem cell transplantation

Cysticercal encephalitis

Tapestry of life The Lancet Volume 375, Issue 9723, (April 2010)

Volume 163, Issue 2, (October 2015)

Symptom-based stratification of autoimmune diseases

A disease of the osteoblast

Presentation transcript:

Immune-mediated necrotising myopathy linked to statin use Dr Stefan Kipfer, MD, Susanna Frigerio, MD, Jürgen Hench, MD, Audrey Aussy, MS, Olivier Boyer, MD The Lancet Volume 386, Issue 10005, (October 2015) DOI: 10.1016/S0140-6736(15)60068-X Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure Necrotising myopathy associated with statin use (A) T1-weighted pelvis MRI showing widespread muscle atrophy (arrow). (B) Haematoxylin and eosin staining showing prominent necrosis without significant inflammation (arrow). (C) Cytoplasmic pattern with perinuclear reinforcement of indirect immunofluorescence on human HEp-2 cells. The Lancet 2015 386, DOI: (10.1016/S0140-6736(15)60068-X) Copyright © 2015 Elsevier Ltd Terms and Conditions