The Vicious Cycle of Chronic Migraine How Can the Physician Help?

This program will include a discussion of data that were presented in abstract form. These data should be considered preliminary until published in a peer-reviewed journal.

Program Overview

Global Burden of Migraine

Loss of Work Time in Patient With Migraine: AMPP Study for 2006

Patient Case History: Sylvia

Patient Case History: Sylvia (cont)

Patient Case: Sylvia's Current Condition

How Common Is Sylvia's Case?

Progression to Chronic Migraine: Sylvia's Case

Risk Factors for Migraine Chronification

Current Evidence-Based Migraine Prevention Treatments: EFNS Guidelines

Complementary Therapies for Migraine

Treatment Choice Based on the Individual

Reasons Reported by Patients for Discontinuation of Preventive Migraine Medication

Revisiting Sylvia's Case

Clinical Approach 1 for Sylvia

Clinical Approach 2 for Sylvia

Clinical Approach 3 for Sylvia

What Do the Guidelines Recommend?

Current Preventive Therapies for Migraine: Unmet Needs

mAbs Targeting the CGRP Pathway for Migraine Prevention

Safety of Anti-CGRP mAbs: Similar to Placebo

Small Molecule CGRP Receptor Blockers: Gepants

Anti-CGRP mAbs: 50% Responder Rates in Chronic Migraine

Reduction in Monthly Acute Migraine-Specific Medication Treatment Days in Chronic Migraine: Erenumab and Fremanezumab

Anti-CGRP mAb CV Safety Findings

Site of Action of CGRP Targeted Drugs: The Trigeminal Ganglion and the BBB

Future Treatment Options for Sylvia: Clinical Opinions

Abbreviations

Abbreviations (cont)