Syntactic Processing Depends on Dorsal Language Tracts

Slides:

Advertisements

Similar presentations

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

Advertisements

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Single Units in the Medial Prefrontal Cortex with Anxiety-Related Firing Patterns Are Preferentially Influenced by Ventral Hippocampal Activity Avishek.

FMRI of the Face-Processing Network in the Ventral Temporal Lobe of Awake and Anesthetized Macaques Shih-Pi Ku, Andreas S. Tolias, Nikos K. Logothetis,

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Volume 63, Issue 3, Pages (August 2009)

Volume 26, Issue 24, Pages (December 2016)

Disrupted Neural Synchronization in Toddlers with Autism

Volume 73, Issue 6, Pages (March 2012)

The Medial Temporal Lobe Supports Conceptual Implicit Memory

Volume 60, Issue 4, Pages (November 2008)

Lior Shmuelof, Ehud Zohary Neuron

Neurodegenerative Diseases Target Large-Scale Human Brain Networks

Volume 55, Issue 3, Pages (August 2007)

Diffusion MRI of Complex Neural Architecture

Cartography and Connectomes

Communicative Signaling Activates ‘Broca's’ Homolog in Chimpanzees

Volume 72, Issue 5, Pages (December 2011)

Genetic Influences on Cortical Regionalization in the Human Brain

Deep Brain Stimulation for Treatment-Resistant Depression

Volume 43, Issue 5, Pages (September 2004)

The Neural Basis of Body Form and Body Action Agnosia

Volume 76, Issue 5, Pages (December 2012)

Michael Ewers, Reisa A. Sperling, William E. Klunk, Michael W

Disruption of Large-Scale Brain Systems in Advanced Aging

Brain Networks and Cognitive Architectures

Insights into Human Behavior from Lesions to the Prefrontal Cortex

Genetic Influences on Cortical Regionalization in the Human Brain

Volume 55, Issue 3, Pages (August 2007)

Volume 63, Issue 3, Pages (August 2009)

Perceptual Learning and Decision-Making in Human Medial Frontal Cortex

Volume 53, Issue 6, Pages (March 2007)

Activity in Both Hippocampus and Perirhinal Cortex Predicts the Memory Strength of Subsequently Remembered Information Yael Shrager, C. Brock Kirwan,

Volume 79, Issue 1, Pages (July 2013)

Jay N. Giedd, Judith L. Rapoport Neuron

Syntactic Processing Depends on Dorsal Language Tracts

Yoni K. Ashar, Jessica R. Andrews-Hanna, Sona Dimidjian, Tor D. Wager

Neural Correlates of Visual Working Memory

Talia Konkle, Aude Oliva Neuron Volume 74, Issue 6, Pages (June 2012)

Integration of Touch and Sound in Auditory Cortex

Improving therapy outcome prediction in major depression using multimodal functional neuroimaging: A pilot study Johannes Schultz, Benjamin Becker, Katrin.

Volume 73, Issue 6, Pages (March 2012)

Distributed Neural Systems for the Generation of Visual Images

Moral Judgments Recruit Domain-General Valuation Mechanisms to Integrate Representations of Probability and Magnitude Amitai Shenhav, Joshua D. Greene

The Functional Neuroanatomy of Object Agnosia: A Case Study

Lior Shmuelof, Ehud Zohary Neuron

The Future of Memory: Remembering, Imagining, and the Brain

Volume 63, Issue 5, Pages (September 2009)

Volume 47, Issue 5, Pages (September 2005)

Interoceptive Basis to Craving

Neural Primacy of the Salience Processing System in Schizophrenia

René Marois, Hoi-Chung Leung, John C. Gore Neuron

Cerebral Responses to Change in Spatial Location of Unattended Sounds

Orienting Attention Based on Long-Term Memory Experience

Neurobiology of Schizophrenia

Brain Mechanisms for Extracting Spatial Information from Smell

The Neural Bases of Cognitive Conflict and Control in Moral Judgment

Volume 47, Issue 6, Pages (September 2005)

Volume 76, Issue 5, Pages (December 2012)

Christian J. Fiebach, Jesse Rissman, Mark D'Esposito Neuron

Sharon L. Thompson-Schill, Mark D'Esposito, Irene P. Kan Neuron

Clinical Concepts Emerging from fMRI Functional Connectomics

A Cool Approach to Probing Speech Cortex

Disintegrating Brain Networks: from Syndromes to Molecular Nexopathies

Volume 72, Issue 5, Pages (December 2011)

Volume 81, Issue 3, Pages (February 2014)

Angela D. Friederici, D. Yves von Cramon, Sonja A. Kotz Neuron

David Hubel and Torsten Wiesel

Presentation transcript:

Syntactic Processing Depends on Dorsal Language Tracts Stephen M. Wilson, Sebastiano Galantucci, Maria Carmela Tartaglia, Kindle Rising, Dianne K. Patterson, Maya L. Henry, Jennifer M. Ogar, Jessica DeLeon, Bruce L. Miller, Maria Luisa Gorno-Tempini Neuron Volume 72, Issue 2, Pages 397-403 (October 2011) DOI: 10.1016/j.neuron.2011.09.014 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Dorsal and Ventral Language Tracts (A–C) Seed ROIs for a single individual (n.b. this was a patient diagnosed with nonfluent PPA). (A) The SLF/Arcuate was seeded from ROIs drawn on a coronal slice posterior to the postcentral gyrus, in the anterior-posteriorly oriented white matter lateral to the corona radiata. (B) The ECFS was seeded from ROIs drawn in anterior-posteriorly oriented white matter on a coronal slice anterior to the precentral gyrus, lateral to the claustrum and external capsule, and medial to the insula. (C) The UF was seeded from ROIs drawn in dorsal-ventrally oriented white matter on an axial slice between the anterior temporal lobe and orbitofrontal cortex. (D–F) The three tracts of interest in representative patients with nonfluent (D), semantic (E), and logopenic (F) variant PPA. (G) Probability maps for the three tracts of interests in all 27 patients. Neuron 2011 72, 397-403DOI: (10.1016/j.neuron.2011.09.014) Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 2 Relationships between Tract Integrity and Syntactic Measures Reduced FA in the left SLF/Arcuate was associated with deficits in syntactic comprehension (A) and production (B). In contrast, there was no relationship between FA in the left ECFS and measures of syntactic comprehension (C) or production (D), and no relationship between FA in the left UF and measures of syntactic comprehension (E) or production (F). Data points are color-coded based on each patient's PPA variant diagnosis. Neuron 2011 72, 397-403DOI: (10.1016/j.neuron.2011.09.014) Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 3 Voxel-Based Morphometry and Functional MRI (A) In the left inferior frontal cortex, reduced gray matter volume was significantly associated with deficits in both comprehension and production of syntax; however, FA in the left SLF/Arcuate predicted syntactic deficits above and beyond atrophy in this region. (B) The left SLF/Arcuate and ECFS were constrained to connect anterior (yellow) and posterior (magenta) language regions that were modulated by syntactic complexity in normal controls in a previous fMRI study (Wilson et al., 2010a). FA values in the constrained SLF/Arcuate were associated with syntactic deficits, but FA values in the constrained ECFS were not. Neuron 2011 72, 397-403DOI: (10.1016/j.neuron.2011.09.014) Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 4 Relationships between Integrity of the Left SLF/Arcuate and Lexical Measures There was no relationship between FA in the left SLF/Arcuate and measures of single word comprehension (A) or production (B). Data points are color-coded based on each patient's PPA variant diagnosis. Neuron 2011 72, 397-403DOI: (10.1016/j.neuron.2011.09.014) Copyright © 2011 Elsevier Inc. Terms and Conditions