Lesley Bailie, Maurice B. Loughrey, Helen G. Coleman Gastroenterology

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Presentation transcript:

Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta- analysis Lesley Bailie, Maurice B. Loughrey, Helen G. Coleman Gastroenterology Volume 152, Issue 1, Pages 92-104 (January 2017) DOI: 10.1053/j.gastro.2016.09.003 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Flow diagram of the study selection process. Gastroenterology 2017 152, 92-104DOI: (10.1053/j.gastro.2016.09.003) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Forest plot of highest vs lowest category of smoking and serrated polyp risk. HPFUS, Health Professionals Follow-Up Study; NHS, Nurses Health Study. Gastroenterology 2017 152, 92-104DOI: (10.1053/j.gastro.2016.09.003) Copyright © 2017 AGA Institute Terms and Conditions

Figure 3 Forest plot of highest vs lowest category of alcohol intake and serrated polyp risk. HPFUS, Health Professionals Follow-Up Study; NHS, Nurses Health Study. Gastroenterology 2017 152, 92-104DOI: (10.1053/j.gastro.2016.09.003) Copyright © 2017 AGA Institute Terms and Conditions

Figure 4 Forest plot of highest vs lowest category of BMI and serrated polyp risk. Gastroenterology 2017 152, 92-104DOI: (10.1053/j.gastro.2016.09.003) Copyright © 2017 AGA Institute Terms and Conditions

Figure 5 Forest plot of highest vs lowest category of physical activity and serrated polyp risk. Gastroenterology 2017 152, 92-104DOI: (10.1053/j.gastro.2016.09.003) Copyright © 2017 AGA Institute Terms and Conditions

Figure 6 Forest plot of highest vs lowest category of medication use and serrated polyp risk. One further RCT (which was not included in meta-analyses due to the different study design) also demonstrated a significant 42% reduced risk for right-sided, but not left-sided, SP when taking 81 mg or 325 mg of aspirin compared with placebo (Wallace et al25). Gastroenterology 2017 152, 92-104DOI: (10.1053/j.gastro.2016.09.003) Copyright © 2017 AGA Institute Terms and Conditions

Figure 7 Forest plot of highest vs lowest category of dietary intakes and serrated polyp risk. HPFUS, Health Professionals Follow-Up Study; NHS, Nurses Health Study. All studies reported dietary intakes comparing highest vs lowest tertile, quartile or quintile of intake, with the exceptions of Lieberman et al,40 which is presented per 100-IU increment of vitamin D intake and per 1-g increment of fat and fiber intakes, and Burnett-Hartman et al,28 which compared ≥3 vs 0 servings red meat/wk. Gastroenterology 2017 152, 92-104DOI: (10.1053/j.gastro.2016.09.003) Copyright © 2017 AGA Institute Terms and Conditions