Treatment of Generalized Tonic-Clonic Seizures in the Modern Era

This program will include a discussion of off-label treatment and investigational agents not approved by the FDA for use in the US.

2017 ILAE Epilepsy Nomenclature

Most Common IGE Syndromes

DRE at UK Epilepsy Referral Clinics

Case 1

Case 1: Care by a General Neurologist

Case 1: Testing, Results, and Diagnosis

Importance of Referral

Apparent Drug Resistance in IGE

Treatment Goals in IGE

Expert Opinion Survey: Design

Expert Opinion Survey: Treatment of IGE With GTCS First Monotherapy

Expert Opinion Survey: Treatment of IGE With GTCS First Monotherapy (cont)

Expert Opinion Survey: Initial AED Selection*

Expert Review: AEDs of Choice

Perampanel: FDA Approved for GTCS

Other Drugs Used for the Treatment of GTCS

Case 2: General History

Case 2: Seizure History

Case 2: Findings and Diagnosis

Case 2: Treatment Considerations

Case 2: Selecting AEDs

Case 2: Treatment Options First Monotherapy

Case 2: Treatment Options First Monotherapy (cont)

Case 2: Treatment Options First Monotherapy (cont)

Case 2: Treatment Options First Monotherapy (cont)

Case 2: Treatment Options First Monotherapy (cont)

Case 2: Treatment Selection

North American AED Pregnancy Registry

Basis of Uncontrolled Seizures With First-Line AED

Case 3: History

Case 3: Selecting AED in DRE

Treating DRE

Conclusions

Abbreviations

Abbreviations