FigS3 IHC analysis of Drosha and DGCR8 protein distribution in the hippocampus, frontal cortex and cerebellum of control cases. In the hippocampus both.

Slides:

Advertisements

Similar presentations

 90 % of the human cerebral cortex is neocortex (also termed isocortex)  It is phylogenetically newest and structurally most complex.  Neocortex is.

Advertisements

Neurobiology Anatomy CS pathway Cerebellar Cortex Cerebellar Deep Nuclei Brainstem Pontine nuclei Interpositus Granule cell Purkinje cell.

NERVOUS SYSTEM Dr Iram Tassaduq SPINAL CORD Externally placed white matter Internally present butterfly shaped grey matter Central canal.

Cerebellum Overview and structure of cerebellum Microcircuitry of cerebellum Motor learning.

Central Nervous System Histology Slide Orientation

Figure 5. Tbr2 and Tbr2-GFP expression in P7 cortex

* Figure A in S1 File Body weight (g) n=8/group

Hippocampal sclerosis and associated focal cortical dysplasia-related epilepsy in neurofibromatosis type I Jordan Gales, Richard A. Prayson Journal.

Fig. 3. (A–L) Descriptive representation of Timm staining in the caudal part of dorsal hippocampus and rostral pole of dorsal CA3 subfields. (A–F) Dentate.

Dysregulation of PINCH signaling in mesial temporal epilepsy

Supplementary Figure 1. ssDNA-positive cells (A, B) and TUNEL-positive

Biphasic Alteration of the Inhibitory Synapse Scaffold Protein Gephyrin in Early and Late Stages of an Alzheimer Disease Model Eva Kiss, Karin Gorgas,

Neuronal connections of the cerebellar cortex: inhibitory elements

Figure S1 a b c d DAPI Lgr β-catenin Merge

Johanna Sigl-Glöckner, Michael Brecht Cell Reports

Organization and Subdivisions of the Cerebellum

NERVOUS SYSTEM Dr Iram Tassaduq. NERVOUS SYSTEM Dr Iram Tassaduq.

Light micrograph of adult rat brain DAB immunostained for Reelin (blue) and counterstained with neutral red for cells (red). Light micrograph of adult.

Volume 8, Issue 4, Pages (August 2002)

Cerebellum January 15, 2008.

STAU1/2 and YBX1 recruit poly-GR/PR into large cytoplasmic granules.

Malat1 is a neuron‐enriched nuclear‐retained ncRNA that is localized to nuclear speckles. Malat1 is a neuron‐enriched nuclear‐retained ncRNA that is localized.

Volume 24, Issue 2, Pages (February 2016)

Adult Neurogenesis and the Vascular Nietzsche

Michael W. Linhoff, Saurabh K. Garg, Gail Mandel Cell

Figure 3 LGI1 and Caspr2 immunohistochemistry on rat brain

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Volume 77, Issue 4, Pages (February 2013)

Laboratory exercises for Brain

App‐CTFs accumulate in the neurites and synaptic compartments in Aph1abc cKO Cre+ brains App‐CTFs accumulate in the neurites and synaptic compartments.

Cytoplasmic poly-GR/PR inclusions resemble stress granules in vitro.

Brain regional vulnerability to anaesthesia-induced neuroapoptosis shifts with age at exposure and extends into adulthood for some regions M. Deng, R.D.

Volume 23, Issue 3, Pages (September 2016)

Poly-GR mainly co-localizes with nucleolar ribosomes.

Volume 2, Issue 5, Pages (November 2000)

New Neurons Maintain Efficient Stress Recovery

Johanna Sigl-Glöckner, Michael Brecht Cell Reports

Volume 18, Issue 9, Pages (September 2010)

Type 1 NSPCs express nestin, ApoE, and GFAP, while mature granule cells make connections with astrocytes expressing ApoE and GFAP. A–D, Representative.

Mutant Loricrin is Not Crosslinked into the Cornified Cell Envelope but is Translocated into the Nucleus in Loricrin Keratoderma Akemi Ishida-Yamamoto,

Volume 64, Issue 5, Pages (December 2009)

Volume 7, Issue 3, Pages (May 2014)

Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain

Impaired TrkB signaling in the cerebellum of Pex14ΔC/ΔC BL/ICR mice.

Volume 16, Issue 5, Pages R147-R151 (March 2006)

Continued. Continued. E, Light microscopic image of the left hippocampus obtained by amygdalohippocampectomy reveals extensive neuronal loss and gliosis.

Altered expression of chondroitin sulfate structure modifying sulfotransferases in the articular cartilage from adult osteoarthritis and Kashin-Beck disease

Functional Integration of Adult-Born Neurons

R.A. Armstrong, P.L. Lantos, N.J. Cairns Pathophysiology

Histopathologic consequences of hyperglycemic cerebral ischemia during hypothermic cardiopulmonary bypass in pigs Brendan P Conroy, MD, Marjorie R Grafe,

Cross-species comparisons.

Endogenous SMN1 is not recruited to stress granules in HeLa cells after diverse stresses. Endogenous SMN1 is not recruited to stress granules in HeLa cells.

Volume 5, Issue 5, Pages (May 2002)

Postmitotic Prox1-deficient DG cells exhibit pyramidal cell morphology

Figure 2 Detection of atypical anti-neuronal antibodies Immunohistofluorescence assay on rat brain sagittal slices incubated with the patient's CSF and.

The complexity and the total dendritic length of ApoE4 adult-born granule cells are significantly reduced. The complexity and the total dendritic length.

Marjorie C. Gondré-Lewis, Robert McGlynn, Steven U. Walkley

Neuronal and glial expression of Nogo-A and synaptic localization of Nogo-A and NgR 1 in the motor cortex. Neuronal and glial expression of Nogo-A and.

Volume 28, Issue 1, Pages (October 2000)

PTZ-induced c-Fos and Arc proteins in hippocampal dentate gyrus

Volume 24, Issue 2, Pages (February 2016)

PTZ-induced neuronal activity visualized by IEGs

Tissue distribution of MMP-9 and MMP-2 in adult rat brain.

Fig. 4. Pathologic findings of Case 2

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Manipulation of Sox11 shifts the abundance of differentiated neurons and apical progenitors. Manipulation of Sox11 shifts the abundance of differentiated.

Limited PD-1 expression in normal human tissues.

Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8 and Stat3+/+:HPV8 mice. Expression of PCNA, K10, and K5 in skin lesions from Stat3+/−:HPV8.

Gdx rats exhibit increased BDNF-ir in the MF pathway.

Volume 21, Issue 5, Pages (November 1998)

Presentation transcript:

FigS3 IHC analysis of Drosha and DGCR8 protein distribution in the hippocampus, frontal cortex and cerebellum of control cases. In the hippocampus both Drosha and DGCR8 show nuclear staining in granular cells In the dentate gyrus (a, b, insets). In frontal cortex both Drosha and DGCR8 are expressed in the nucleus of neurons in superficial and deep cortical layers (c, d, insets). In the cerebellum, granule cells and Purkinje cells show mainly nuclear staining (e and f, insets). No NCI or DNs are observed in any of the control cases analyzed. Scale bar; 100μm (a, b, c, d) and 50μm (e-f)