A Proposal for Definition of Minimally Invasive Adenocarcinoma of the Lung Regardless of Tumor Size Shigeki Suzuki, MD, Hiroyuki Sakurai, MD, Kyohei.

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A Proposal for Definition of Minimally Invasive Adenocarcinoma of the Lung Regardless of Tumor Size Shigeki Suzuki, MD, Hiroyuki Sakurai, MD, Kyohei Masai, MD, Keisuke Asakura, MD, Kazuo Nakagawa, MD, Noriko Motoi, MD, Shun- ichi Watanabe, MD The Annals of Thoracic Surgery Volume 104, Issue 3, Pages 1027-1032 (September 2017) DOI: 10.1016/j.athoracsur.2017.02.067 Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Schema for the study population. The Annals of Thoracic Surgery 2017 104, 1027-1032DOI: (10.1016/j.athoracsur.2017.02.067) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Example of pathologic tumor larger than 3.0 cm with invasion of 0.5 cm or less. (A) Ground glass nodule detected on thin-slice computed tomography; the largest diameter of this lesion is 5.4 cm and includes a 0.3 cm solid component. (B) Hematoxylin and eosin stain of the same lesion’s surgical specimen. Pathologic tumor size is 4.7 cm and includes 0.4 cm invasive component. The Annals of Thoracic Surgery 2017 104, 1027-1032DOI: (10.1016/j.athoracsur.2017.02.067) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Overall survival (OS) and cancer-specific survival (CSS) curves for all 18 lung cancer patients with pathologic tumor size larger than 3.0 cm and invasion 0.5 cm or less. The 5-year (yr) overall and cancer-specific survival rates are 94.4% and 100%, respectively. The Annals of Thoracic Surgery 2017 104, 1027-1032DOI: (10.1016/j.athoracsur.2017.02.067) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Survival comparison between lepidic adenocarcinoma (LA) larger than 3.0 cm with invasion 0.5 cm or less and minimally invasive adenocarcinoma (MIA) 3.0 cm or less in our database. Five-year (yr) overall survival (OS) rates of lepidic adenocarcinoma larger than 3.0 cm with invasion 0.5 cm or less and minimally invasive adenocarcinoma were 94.4% and 100%, respectively, with no significant statistical difference in overall survival between groups (p = 0.15). The Annals of Thoracic Surgery 2017 104, 1027-1032DOI: (10.1016/j.athoracsur.2017.02.067) Copyright © 2017 The Society of Thoracic Surgeons Terms and Conditions