Strength in Diversity Cell Host & Microbe

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Strength in Diversity Cell Host & Microbe Daniel J. Wolter, Lucas R. Hoffman Cell Host & Microbe Volume 16, Issue 4, Pages 427-429 (October 2014) DOI: 10.1016/j.chom.2014.09.018 Copyright © 2014 Elsevier Inc. Terms and Conditions

Figure 1 Impact of Community Interactions on the Growth and Virulence of Slow-Growing Bacteria A metabolically deficient small colony variant (SCV, center) has significantly impaired growth and decreased virulence factor production in vitro and lower bacterial burdens and virulence in an osteomyelitis infection model (indicated by gray lesions in bone) compared to bacteria with normal growth (left). However, cocultures of two SCVs (SCV-1 and SCV-2, right) with distinct metabolic deficiencies results in enhanced growth and virulence in vitro and in vivo, probably through the intercellular transfer of metabolites. Cell Host & Microbe 2014 16, 427-429DOI: (10.1016/j.chom.2014.09.018) Copyright © 2014 Elsevier Inc. Terms and Conditions