Cell-type–specific ERV expression in primary cells.

Slides:



Advertisements
Similar presentations
Basic Spreadsheet Functions Objective Functions are predefined formulas that perform calculations by using specific values, called arguments, in.
Advertisements

Histograms. Definition of a Histogram A Histogram displays a range of values of a variable that have been broken into groups or intervals. Histograms.
High-dimensional analysis of lymphoid CD4+ T cells identified distinct TFH cell subsets in HIV+ patients and HCs. High-dimensional analysis of lymphoid.
Comparison (θ) of the mean dinucleotide variability distribution for (A) genes with MAE vs. Comparison (θ) of the mean dinucleotide variability distribution.
Comparison (R) of the mean observed to expected dinucleotide distribution for (A) genes with MAE vs. Comparison (R) of the mean observed to expected dinucleotide.
(A) Heat map showing expression changes during in vitro differentiation of nscs to astrocytes. (A) Heat map showing expression changes during in vitro.
New archeological excavations in San Marcos cave.
Identification of imprinted genes and imprinted DMRs
Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25 cells. Expression of α5β1-integrin enhances EboV GP-mediated infection of GD25.
CatL activity levels and expression of the DC forms of CatB and CatL are reduced in the α5β1-negative CHO cells. CatL activity levels and expression of.
Ongoing DNA damage, induction of cellular senescence, and acquisition of the senescence-associated secretory phenotype 12 mo after 56Fe radiation. Ongoing.
Pig iPSCs are reprogrammed differently and show genome-wide hypomethylation compared with mouse and human. Pig iPSCs are reprogrammed differently and show.
ERVmap reveals additional breast cancer-associated ERVs that correlate with cytolytic activity. ERVmap reveals additional breast cancer-associated ERVs.
Schematic of elephant ivory showing longitudinal cross-section of a tusk with pulp cavity, dentine, and cementum. Schematic of elephant ivory showing longitudinal.
Deep neural networks (DNNs) can successfully identify, count, and describe animals in camera-trap images. Deep neural networks (DNNs) can successfully.
Pretreatment of VSV-GPΔ to form VSV-GP19K rescues infection in the α5β1-integrin-negative CHO cells. Pretreatment of VSV-GPΔ to form VSV-GP19K rescues.
RGFP-966 decreases HDAC3 activity and is not cytotoxic.
Motor coordination is enhanced by genetic deletion of Best1 or MAOB but impaired by overexpression of MAOB. (A) Experimental timeline and schematic illustration.
HDAC3 silencing promotes nonamyloidogenic APP processing and decreases Aβ1–42:Aβ1–40 ratio. HDAC3 silencing promotes nonamyloidogenic APP processing and.
(A) Box and whisker diagram for median lag times (difference between date of death and seizure date) of ivory specimens analyzed in this study; the number.
Social activity of humans and bots over time.
Patients with SLE have elevated ERV expression.
Estimation of R(t). Estimation of R(t). (A) Daily R(t) as inferred from the daily incidence of new infections for one stochastic model realization. Tg.
Despite a relatively small amount of PI3Kβ being associated with activated PDGFRs, it generates a more substantial proportion of the PIP3 that accumulates.
Summary of fusion event frequency for wild-type (wt) and Cav1
Variance priming. Variance priming. (A) Mean RTs for both levels of prime variance (x axis; high or low) and both levels of target variance (lines; high.
Host transcriptional profiling distinguishes patients with acute LRTI (LRTI+C+M) from those with noninfectious acute respiratory illness (no-LRTI). Host.
Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO mice. Postnatal lethality, pleural effusion in endothelial-specific Piezo1 cKO.
Reversible control of cell-level molecular timekeeping by translational switching of Cry1 expression in Cry-null SCN slices. Reversible control of cell-level.
Effect of dorsal rhizotomy on CaV2
Submitochondrial localization of mitofilin using quantitative immunoelectron microscopy. Submitochondrial localization of mitofilin using quantitative.
Mitofilin cluster distribution is denser in the perinuclear mitochondria. Mitofilin cluster distribution is denser in the perinuclear mitochondria. (A)
RGFP-966 increases H4K12 acetylation in HEK/APPsw cells.
PCA of RNAseq data from CTL TB and EOPE TB (GSE119265).
STED microscopy of MINOS
Immunofluorescece analysis of c-src and v-src distribution in wild-type yeast cells. Immunofluorescece analysis of c-src and v-src distribution in wild-type.
Expression of NCoR1∆ID in PAX8−/− mice does not reverse repression of T3-positive target genes. qPCR on the indicated pituitary (A) and neuronal (B) genes.
GC analysis of V4 feedback modulations based on LFP data.
Sleep/wake phenotype of S551D mutant mice.
Role of IL-27 in expression of PD-L1, LAG-3, and CTLA-4 depends on strength of α-CD3/28 signaling. Role of IL-27 in expression of PD-L1, LAG-3, and CTLA-4.
ICSBP stimulates GAS reporter activity in JAK/STAT-pathway-deficient cells. 2fTGH, U3A, U4A, and γ1A cells were cotransfected with the WT GAS reporter.
Phylogeny of VexL pectate lyases.
Volume 16, Issue 2, Pages (February 2015)
Pyoverdine production measured as RFUs standardized by OD significantly decreases with length of infection in years. Pyoverdine production measured as.
Lymphocyte lineage trees produced by long-term live cell microscopy.
Identification of candidate genes within the 1q32 locus.
Rescue of the sel-12 Egl phenotype by PS1 and PS1ΔE9 expressed from arrays formed at a concentration of 2 μg/ml. Rescue of the sel-12 Egl phenotype by.
Activation of Gα subunit chimeras with noncognate C termini.
Schematic representation of our random walk model with environmental state-dependent dynamics. Schematic representation of our random walk model with environmental.
Tissue-specific transcriptome responses to fasting.
Structure and receptor-binding properties of SCH-C.
BHLH1a localizes in the nucleus, and its overexpression alters rhythmic diel gene expression. bHLH1a localizes in the nucleus, and its overexpression alters.
Light dependency of Prochlorococcus mortality forces.
Differential expression of TRM markers by donor- and recipient-derived T cells with time. Differential expression of TRM markers by donor- and recipient-derived.
Consistency of results across images and time.
(A) Spatial distribution of plague spread during the Third Pandemic.
High-dimensional analysis of IL-10–dependent regulation of the antiviral response in the lung and the colon. High-dimensional analysis of IL-10–dependent.
TNAP and IAP t1/2s and N-glycan remodeling following zanamivir treatment. TNAP and IAP t1/2s and N-glycan remodeling following zanamivir treatment. (A.
Cell viability tests. Cell viability tests. SEM images of (A) MC3T3-E1 cells and (B) MSCs on days 1, 3, and 5 of culture. (C) Survival rates of MC3T3-E1.
How upland and lowland alleles contribute to the optimal genotype at each field site. How upland and lowland alleles contribute to the optimal genotype.
Mapping positions of QTL across five traits
Histograms.
Fluorescence assays of diameter dependent cellular toxicity.
IL-27 induces expression of multiple IR by CD8+ T cells.
Fig. 3 The rs risk enhancer is a hub for intrachromosomal and interchromosomal interactions. The rs risk enhancer is a hub for intrachromosomal.
Integrated mRNA and microRNA expression and DNA methylation clusters.
EN1 expression in breast cancer and clinical outcome.
Initial testing and characterization of cAMPr in ES cells.
Phenotypic diversity of individual multiple myeloma clones.
Pancreatic adenocarcinoma, chronic pancreatitis, and normal pancreas samples can be distinguished on the basis of gene expression profiling. Pancreatic.
Presentation transcript:

Cell-type–specific ERV expression in primary cells. Cell-type–specific ERV expression in primary cells. (A) Cell types and associated information for each sample used in the ERV analysis. (B) Histogram of the amount of reads attributed to each of the 3,220 ERV loci sorted in order of highest to lowest expressed ERVs for each cell type. For cell types with multiple samples, the average number of reads per locus was plotted. (C) Sum of all ERV reads per sample compared across cell types. For cell types with multiple datasets, the average and SEM are graphed. (D) Heatmap of ERVs that are expressed across indicated cell types. The 500 most varying ERVs were used for the analysis to reduce noise. Two-dimensional t-SNE analysis (E) and PCA (F) of ERVs expressed by indicated cell types using the same set of 500 ERVs as in D. t-SNE analysis was performed using a perplexity of 30 and maximum iteration of 1,000. Maria Tokuyama et al. PNAS doi:10.1073/pnas.1814589115 ©2018 by National Academy of Sciences