Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation.

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Presentation transcript:

Evaluation of early administration of simvastatin in the prevention and treatment of delirium in critically ill patients undergoing mechanical ventilation (MoDUS): a randomised, double-blind, placebo-controlled trial Dr Valerie J Page, MBBCh, Annalisa Casarin, MD, Prof E Wesley Ely, MD, Xiao Bei Zhao, BSc, Cliona McDowell, MSc, Lynn Murphy, BSc, Prof Daniel F McAuley, MD The Lancet Respiratory Medicine Volume 5, Issue 9, Pages 727-737 (September 2017) DOI: 10.1016/S2213-2600(17)30234-5 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Trial design *Some categories are double counted to allow for patients who met multiple criteria (appendix p 11). IMP=investigational medicinal product. The Lancet Respiratory Medicine 2017 5, 727-737DOI: (10.1016/S2213-2600(17)30234-5) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 2 Kaplan-Meier plot for all cause mortality at 6 months HR=hazard ratio. The Lancet Respiratory Medicine 2017 5, 727-737DOI: (10.1016/S2213-2600(17)30234-5) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 3 Kaplan-Meier plot for time to discharge from hospital HR=hazard ratio. The Lancet Respiratory Medicine 2017 5, 727-737DOI: (10.1016/S2213-2600(17)30234-5) Copyright © 2017 Elsevier Ltd Terms and Conditions