Clayton Wiley, M.D./PhD.

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Presentation transcript:

Clayton Wiley, M.D./PhD

Question 1 A 5-year-old girl presents with a ~6 week history of early morning headaches. Describe the findings in her MRI scan.

T1

T1 plus contrast

T1 plus contrast

Question 2 What is your major differential diagnosis for posterior fossa tumors in children?

Answer Ependymoma Pilocytic astrocytoma Medulloblastoma

Question 3 An intraoperative consultation was requested and performed via telepathology. Describe the findings in the intraoperative smear preparation on the following representative snapshots obtained via the telepathology system.

Question 4 What is your intraoperative diagnosis?

Answer Medulloblastoma

Question 5 A resection of the mass was performed. Describe the findings in the following representative permanent H&E slide. Click here to view slide.

Question 8 Describe the findings in the following immunohistochemical slides for synaptophysin and Ki-67. Click here to view slide