Gheorghe Chistol, Johannes C. Walter Cell

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Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing Gheorghe Chistol, Johannes C. Walter Cell Volume 161, Issue 3, Pages 429-430 (April 2015) DOI: 10.1016/j.cell.2015.04.006 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Loading Stages of the Eukaryotic Replicative Helicase During G1, the eukaryotic replicative helicase is loaded as a preRC complex at the replication origin (ACS in yeast). Each preRC consists of two MCM2–7 hexamers encircling dsDNA. Establishing the necessary head-to-head association of the hexamers involves cooperation between the origin recognition complex (ORC) and licensing factors Cdc6 and Cdt1. At the beginning of the S phase, the preRC is activated and associates with Cdc45 and GINS to form two CMG complexes that travel on ssDNA away from the origin. Ticau et al. dissected the stages of preRC loading. Cell 2015 161, 429-430DOI: (10.1016/j.cell.2015.04.006) Copyright © 2015 Elsevier Inc. Terms and Conditions