George E. Georges, Vladimir Lesnikov, Szczepan W

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Presentation transcript:

A Preclinical Model of Double- versus Single-Unit Unrelated Cord Blood Transplantation George E. Georges, Vladimir Lesnikov, Szczepan W. Baran, Anna Aragon, Marina Lesnikova, Robert Jordan, Ya-Ju Laura Yang, Murad Y. Yunusov, Eustacia Zellmer, Shelly Heimfeld, Gopalakrishnan M. Venkataraman, Michael A. Harkey, Scott S. Graves, Rainer Storb, Barry E. Storer, Richard A. Nash Biology of Blood and Marrow Transplantation Volume 16, Issue 8, Pages 1090-1098 (August 2010) DOI: 10.1016/j.bbmt.2010.03.010 Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 The absolute neutrophil count (ANC) and platelet count per microliter (log10 scale) from dogs receiving unrelated cord blood transplantation (CBT) on day 0 after 9.2 Gy TBI. (A) Double-unit CBT group. (B) Single-unit CBT group. Each line/symbol represents blood counts from individual dogs. ET, euthanized because of meeting defined criteria of poor condition after transplantation (for details, see Tables 3 and 4). Biology of Blood and Marrow Transplantation 2010 16, 1090-1098DOI: (10.1016/j.bbmt.2010.03.010) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Serial chimerism analyses from peripheral blood mononuclear cells for 5 dogs that received double unit unrelated cord blood transplantation. The first infused donor unit had the lower total cell dose. Each cord blood unit cell dose is shown in parenthesis (TNC × 107/kg). Granulocyte chimerism for the dominant unit was consistently ≥% PBMC chimerism (data not shown). Biology of Blood and Marrow Transplantation 2010 16, 1090-1098DOI: (10.1016/j.bbmt.2010.03.010) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 (A) Immune recovery of T and B cell subsets in 4 dogs after double-unit unrelated cord blood transplantation (CBT). Shaded region indicates normal range of values (median ± 1 standard deviation from 20 untreated dogs). (B) Primary and secondary antibody titer response against the neoantigen sheep red blood cells injected on day +148-184 and +218-248 after CBT, respectively. Biology of Blood and Marrow Transplantation 2010 16, 1090-1098DOI: (10.1016/j.bbmt.2010.03.010) Copyright © 2010 American Society for Blood and Marrow Transplantation Terms and Conditions