Fig. 7. Gradient of adipocyte size and FAI around the human coronaries in the presence or absence of coronary atherosclerosis. Gradient of adipocyte size.

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Fig. 7. Gradient of adipocyte size and FAI around the human coronaries in the presence or absence of coronary atherosclerosis. Gradient of adipocyte size and FAI around the human coronaries in the presence or absence of coronary atherosclerosis. (A) PPAR-γ, (B) CEBPA, and (C) CEBPA4 gene expression and (D) adipocyte size in pericoronary adipose tissue samples attached to the RCA and paired samples ~20 mm away from it [n = 6 to 12 pairs for (A) to (D)]. (E to G) In study arm 3, FAI around the RCA of patients undergoing CTA was calculated for each cylindrical 1-mm-thick layer of pericoronary tissue, whereas for a radial distance, FAI was calculated from RCA wall 1 to 20 mm. (H) FAI mapping of PVAT around the RCA. (I) FAI and radial distance from vascular wall in patients with CAD (n = 149) versus healthy individuals (n = 117) [comparison of the area under the curve (AUC) using unpaired t test and comparison of the curves using two-way ANOVA for repeated measures with “FAI × distance” interaction]. P values by Wilcoxon signed-rank test (A to D). Alexios S. Antonopoulos et al., Sci Transl Med 2017;9:eaal2658 Published by AAAS