Fat Chance for Neural Stem Cells in Alzheimer’s Disease

Slides:

Advertisements

Similar presentations

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Advertisements

Distribution of Human Embryonic Stem Cell Lines: Who, When, and Where Jennifer B. McCormick, Jason Owen-Smith, Christopher Thomas Scott Cell Stem Cell.

Eph-Ephrin Bidirectional Signaling in Physiology and Disease Elena B. Pasquale Cell Volume 133, Issue 1, Pages (April 2008) DOI: /j.cell

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

IPSC Crowdsourcing: A Model for Obtaining Large Panels of Stem Cell Lines for Screening Mahendra Rao Cell Stem Cell Volume 13, Issue 4, Pages (October.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

CDK Inhibitors: Cell Cycle Regulators and Beyond Arnaud Besson, Steven F. Dowdy, James M. Roberts Developmental Cell Volume 14, Issue 2, Pages

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle Isabel Beerman, Jun Seita, Matthew A.

Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells Keriayn N. Smith, Amar M. Singh, Stephen Dalton Cell Stem Cell Volume 7, Issue.

Normal and Leukemic Stem Cell Niches: Insights and Therapeutic Opportunities Koen Schepers, Timothy B. Campbell, Emmanuelle Passegué Cell Stem Cell Volume.

Quantitative Single-Cell Approaches to Stem Cell Research Martin Etzrodt, Max Endele, Timm Schroeder Cell Stem Cell Volume 15, Issue 5, Pages (November.

Stress Can Be a Good Thing for Blood Formation

Of Brains and Blood: Developmental Origins of Glioma Diversity?

Scott N. Freeman, Kathryn A. Burke, Menfo A. Imoisili, Timothy R. Coté

Valeria V. Orlova, Christine L. Mummery Cell Stem Cell

Volume 1, Issue 1, Pages (June 2007)

Human Induced Pluripotent Stem Cells: Now Open to Discovery

MicroRNA-124: Micromanager of Neurogenesis

Volume 12, Issue 2, Pages (February 2013)

The LUNGe to Model Alveolar Lung Diseases in a Dish

Volume 16, Issue 6, Pages (June 2015)

There's No Place Like Home for a Neural Stem Cell

Gerry P. Crossan, Juan I. Garaycoechea, Ketan J. Patel Cell Stem Cell

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

Anselme Perrier, Marc Peschanski Cell Stem Cell

Home at Last: Neural Stem Cell Niches Defined

Neural Circuits Serve as Periscopes for NSCs

Transplantable Liver Organoids Made from Only Three Ingredients

Small Molecules Take a Big Step by Converting Fibroblasts into Neurons

Revealing the Hidden Powers that Fuel Adult Neurogenesis

Stem Cell Therapies in Clinical Trials: Progress and Challenges

Human Induced Pluripotent Stem Cells: Now Open to Discovery

Amyloid Structures from Alzheimer’s Disease Patients

CHD7 in Charge of Neurogenesis

Appetite for Neurogenesis

Of Brains and Blood: Developmental Origins of Glioma Diversity?

Blocking HIF1α Activity Eliminates Hematological Cancer Stem Cells

Da Yong Lee, Scott M. Gianino, David H. Gutmann Cancer Cell

Utf1: Goldilocks for ESC Bivalency

Volume 19, Issue 5, Pages (November 2016)

Volume 46, Issue 5, Pages (June 2012)

Erika Pastrana, Violeta Silva-Vargas, Fiona Doetsch Cell Stem Cell

Not So Lonely at the Top for Cancer Stem Cells

Integrin Alpha 6: Anchors Away for Glioma Stem Cells

Volume 18, Issue 2, Pages (February 2016)

Puma: Mauling the Intestinal Crypt

Off the Beaten Track: New Neurons in the Adult Human Striatum

A Coated Sponge: Toward Neonatal Brain Repair

Transplantable Liver Organoids Made from Only Three Ingredients

Looking Back: Aging and Regeneration

Notch in the Vertebrate Nervous System: An Old Dog with New Tricks

Gunapala Shetty, Marvin L. Meistrich Cell Stem Cell

Tracing Stem Cell Division in Adult Neurogenesis

Powering Reprogramming with Vitamin C

Volume 7, Issue 6, Pages (December 2010)

Restraining Stem Cell Niche Plasticity: A New Talent of Eph Receptors

Amyloid Structures from Alzheimer’s Disease Patients

Regulating Autologous Adult Stem Cells: The FDA Steps Up

NO Signals from the Cancer Stem Cell Niche

Sensors of Succinate: Neural Stem Cell Grafts Fight Neuroinflammation

Pushing and Pulling on Adult Neural Stem Cells

Adult Neural Stem Cells Bridge Their Niche

There's No Place Like Home for a Neural Stem Cell

Selfish Stem Cells Compete with Each Other

Guo-li Ming, Hongjun Song Neuron Volume 70, Issue 4, Pages (May 2011)

Volume 22, Issue 4, Pages (April 2018)

Regulating Autologous Adult Stem Cells: The FDA Steps Up

Taking Neural Crest Stem Cells to New Heights

Rejuvenation: It’s in Our Blood

Mark C. Horowitz, Steven M. Tommasini Cell Stem Cell

Presentation transcript:

Fat Chance for Neural Stem Cells in Alzheimer’s Disease Geraldine Gontier, Karin Lin, Saul A. Villeda Cell Stem Cell Volume 17, Issue 4, Pages 373-374 (October 2015) DOI: 10.1016/j.stem.2015.09.006 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Lipid Accumulation Negatively Regulates Neural Stem Cell Function in a Mouse Model of Alzheimer’s Disease Oleic acid (yellow) accumulates in ependymal cells (gray) in the Alzheimer’s disease (AD) subventricular zone (SVZ) at young ages, resulting in decreased neural stem cell (NSC) (blue) and transient amplifying cell (teal) proliferation that leads to reduced neurogenesis (green). Negative regulation of NSC activity is mitigated by local inhibition of oleic acid production with SCD1 inhibitor in the young AD SVZ. (WT, wild-type; LV, lateral ventricle; BV, blood vessel). Illustration courtesy of Gregor Bieri. Cell Stem Cell 2015 17, 373-374DOI: (10.1016/j.stem.2015.09.006) Copyright © 2015 Elsevier Inc. Terms and Conditions