MicroRNA-124: Micromanager of Neurogenesis Thales Papagiannakopoulos, Kenneth S. Kosik  Cell Stem Cell  Volume 4, Issue 5, Pages 375-376 (May 2009) DOI: 10.1016/j.stem.2009.04.007 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 miR-124 Positively Regulates Adult SVZ Neurogenesis In a sagittal section of an adult mouse brain, adult neurogenesis occurs from the SVZ through the RMS, ultimately ending at the OB. miR-124 expression increases (red gradient) as the migratory differentiation cascade gives rise to neurons. miR-124 exerts its effect by targeting Sox9 and other repressors of neurogenesis. REST represses miR-124 expression in the SVZ progenitor pool. Cell Stem Cell 2009 4, 375-376DOI: (10.1016/j.stem.2009.04.007) Copyright © 2009 Elsevier Inc. Terms and Conditions