Key amino acid positions identified by association analysis are highlighted in three-dimensional ribbon models for the HLA-DR, HLA-DQ, HLA-A and HLA-DP.

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Key amino acid positions identified by association analysis are highlighted in three-dimensional ribbon models for the HLA-DR, HLA-DQ, HLA-A and HLA-DP proteins. Key amino acid positions identified by association analysis are highlighted in three-dimensional ribbon models for the HLA-DR, HLA-DQ, HLA-A and HLA-DP proteins. All protein structures are positioned to accommodate the view of the peptide binding groove and the associated amino acid residues using UCSF Chimera. (A) Three-dimensional ribbon model for the HLA-DR protein with positions 11 and 13 located on the β-sheet floor within the antigen binding groove. (B) Three-dimensional ribbon model for the HLA-DQ protein with position 45 in the β-turn of the HLA-DQ protein. (C) Three-dimensional ribbon model for the HLA-A protein with position 156 located in the β-sheet floor in the peptide-binding groove. (D) Three-dimensional ribbon model for the HLA-DP protein with position 76 in the β-sheet floor. Ricong Xu et al. JASN 2017;28:3383-3394 ©2017 by American Society of Nephrology