Marwan Badri et al. JACEP 2015;1:

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Marwan Badri et al. JACEP 2015;1:315-322 Effect of Mexiletine on QT Interval and TdP Electrocardiogram (ECG) strips of 4 cases displaying long QT pre-mexiletine, followed by torsade de pointes (TdP), and post-mexiletine ECG strips. In case A, the post-mexiletine ECG was recorded 24 h after the first dose and after a total of 400 mg. In case B, it was recorded 15 h after the first dose and after a total of 300 mg. In case C, the post-mexiletine ECG was recorded 25 h after the first dose and after 600 mg of mexiletine. In case D, the post-mexiletine ECG was recorded 23 h after the first dose and after a total of 600 mg. Note that all 4 episodes of TdP occurred following a long-short interval. Marwan Badri et al. JACEP 2015;1:315-322 American College of Cardiology Foundation